Results 101 to 110 of about 86,395 (301)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs

, 1979
Dante Borelli, José L. Bran, J. Fuentes, R. Legendre, Eduardo A Leiderman, H. B. Levine, Angela Restrepo-M., David A. Stevens   +7 more
openalex   +1 more source

Self-medication with vaginal antifungal drugs: physicians' experiences and women's utilization patterns [PDF]

, 2000
Sinikka Sihvo, Riitta Ahonen, H. Mikander, Elina Hemminki   +3 more
openalex   +1 more source

Dnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression

Advanced Science, EarlyView.
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu   +8 more
wiley   +1 more source

Exploring synergy between azole antifungal drugs and statins for Candida auris. [PDF]

J Antimicrob Chemother, 2023
Halliday C, Kim HY, Tay E, Chen SCA, Alffenaar JW.   +4 more
europepmc   +1 more source

In vitro susceptibility of Cryptococcus neoformans isolates to five antifungal drugs using a colorimetric system and the reference microbroth method [PDF]

, 2000
Olga López-Jodra
openalex   +1 more source

SIP‐SRS Imaging of Cell Wall Synthesis Identifies a Synergy between Micafungin and Amphotericin B

Advanced Science, EarlyView.
We employed glucose‐d7–based stable isotope probe‐assisted SRS microscopy (SIP‐SRS) C–D imaging to visualize fungal cell wall synthesis and remodeling under antifungal treatment. Amphotericin B (AmB) induced notable daughter cell wall thickening, prompting a combinational therapy with AmB and micafungin.
Meng Zhang, Yuewei Zhan, Haonan Lin, Jiyang Chen, Mohamed N. Seleem, Michael Mansour, Ji‐Xin Cheng   +6 more
wiley   +1 more source

ANTIFUNGAL THERAPY AND PESTICIDES: IS THERE A CONNECTION?

Клінічна та профілактична медицина
Introduction. During the last decades, the resistance of fungi to antifungal drugs has remained one of the key problems of practical medicine and medical science and requires in-depth study.
Anastasiia A. Hrynzovska, Vitaly V. Bobir, Volodymyr P. Shirobokov, Irina M. Vovk, Vadym A. Poniatovsky, Oleksandr A. Nazarchuk   +5 more
doaj   +1 more source

Studies on antifungal mechanism of action of butenafine hydrochloride. II. Comparison in the response to drug treatment between a wild-type strain and tolciclate-resistant mutant strains of Sporothrix schenckii.

, 1991
Tamio Hiratani, Yukiyo Asagi, Hideyo Yamaguchi   +2 more
openalex   +2 more sources

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, EarlyView.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source