Results 111 to 120 of about 86,395 (301)
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Counterpoint: Alternative Trial Designs for Antifungal Drugs—Time to Talk [PDF]
, 2001 John H. Powers
openalex +1 more source
Electrochemical Approach to Organonitrogen Compounds via C–N Coupling
Advanced Science, EarlyView.This review summarizes recent advances in electrocatalytic C–N coupling for organonitrogen electrosynthesis. It discusses innovative strategies for catalyst design and the electrosynthesis of diverse organonitrogen compounds, including urea, oximes, amino acids, amides, and amines. Additionally, it outlines future opportunities for sustainable C–N bond
Haifei Liu, Wenbo Wei, Qi‐Long Zhu
wiley +1 more source
Changing Self‐Assembly Through Degradation: Phenyl Vinyl Ketone Polymer Nanoparticles Under Light
Angewandte Chemie, EarlyView.Photodegradable nanoparticles with sphere, worm, and vesicle morphologies are created via PISA using photo responsive PVK and non‐responsive HPMA blocks. Under UV light, worms quickly transform into spheres, while spheres and vesicles retain their shapes despite chain scission. Degradation also tailors surface properties and enables controlled release,
M. A. Sachini N. Weerasinghe +3 more
wiley +2 more sources
Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs. [PDF]
Pharmaceutics, 2023 Xin Y, Quan L, Zhang H, Ao Q.
europepmc +1 more source
Advanced Science, EarlyView.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source
Angewandte Chemie, EarlyView.Fluorine nuclear spins can be hyperpolarized in solution by Overhauser dynamic nuclear polarization from a paramagnetic agent like galvinoxyl. This hyperpolarization can be transferred by nuclear magnetic resonance (NMR) to nearby 13C, leading to 13C signal enhancements up to ∼100.
Maik Reinhard +7 more
wiley +2 more sources
The Antifungal Drug Amphotericin B Promotes Inflammatory Cytokine Release by a Toll-like Receptor- and CD14-dependent Mechanism [PDF]
, 2003 Keya Sau +5 more
openalex +1 more source
Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine
Aggregate, EarlyView.Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang +7 more
wiley +1 more source
Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs
Angewandte Chemie, EarlyView.A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee +4 more
wiley +2 more sources