Results 231 to 240 of about 86,395 (301)
Chemistry &Biodiversity, EarlyView.ABSTRACT Plinia cauliflora (DC.) Kausel (jabuticaba) is traditionally used by Brazilian indigenous communities for therapeutic purposes, including the treatment of wounds and inflammation. This study investigated the phytochemical composition and biological activities of an ethanolic extract derived from P.
Priscila de Lima Paula +17 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The Casearia genus (Salicaceae) is well known as a source of natural antitumor prototypes, as described for clerodane diterpenes. In this way, the dichloromethane phase from leaves of Casearia arborea was phytochemically evaluated in liquid chromatography coupled to high‐resolution mass spectrometry, furnishing flavonoid, flavolignan, and ...
Augusto L. Santos +7 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim +8 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT Pistacia species are widely used in traditional medicine, particularly for wound healing. This study investigated the fatty acid composition of fruits from four Pistacia species collected from various regions of Algeria. Dried fruits of Pistacia lentiscus L. were extracted using hexane in a Soxhlet apparatus.
Ahmed Boukelouaa +7 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Namrita Lall +9 more
wiley +1 more source
What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugs. [PDF]
Antimicrob Agents ChemotherRhodes J +8 more
europepmc +1 more source
Oxygenated Solanapyrone Analogs From Nigrospora sp. IQ‐064, a Mangrove Associated Fungus
Chemistry &Biodiversity, EarlyView.ABSTRACT Two new oxygenated solanapyrone analogues, nigrosporapyrone E (1) and nigrosporapyrone F (2), were isolated from Nigrospora sp. strain IQ‐064, a fungus associated with the bark of black mangrove (Avicennia germinans L.), along with seven known compounds.
Carlos A. Fajardo‐Hernández +4 more
wiley +1 more source
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, EarlyView.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT Oral mucositis is a frequent and painful complication of cancer therapy with limited effective options. This study evaluated a mucoadhesive polyvinyl alcohol (PVA) film containing 2.5% Fridericia chica extract as a novel strategy. The formulation was characterized for antioxidant activity, phenolic and flavonoid content, and reactive species ...
Ilza Maria de Oliveira Sousa +12 more
wiley +1 more source