Results 91 to 100 of about 502,199 (230)

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Beyond Conventional Antifungals: Combating Resistance Through Novel Therapeutic Pathways

Pharmaceuticals
The rising burden of fungal infections presents a significant challenge to global healthcare, particularly with increasing antifungal resistance limiting treatment efficacy.
Helal F. Hetta, Tameem Melhem, Hashim M. Aljohani, Ayman Salama, Rehab Ahmed, Hassabelrasoul Elfadil, Fawaz E. Alanazi, Yasmin N. Ramadan, Basem Battah, Michelangelo Rottura, Matthew Gavino Donadu   +10 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance

, 2009
The accuracy of antifungal susceptibility testing is important for reliable resistance surveillance and for the clinical management of patients with serious infections due to Candida spp.
KROEGER J, HOLLIS RJ, TENDOLKAR S, PARTICIPANT OF GLOBAL ANTIFUNGAL SURVEILLANCE GROUP, GHEZZI, Maria Cristina, MESSER SA, RAPONI, Giammarco, DIEKEMA DJ, PFALLER MA, BOYKEN L   +9 more
core   +1 more source

CARD9⁺ Microglia Orchestrate Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment [PDF]

, 2019
The C-type lectin receptor/Syk adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human CARD9-deficiency causes fungal-specific CNS-targeted infection susceptibility.
Katrin D. Mayer-Barber, Lira, Sergio A., Drummond, Rebecca A.; id_orcid, Schaefer, Brian C., Oikonomou, Vasileios, Naglik, Julian R., Muthulekha Swamydas, Zhai, Bing, Naglik, Julian R, Dambuza, Ivy, Tobias M. Hohl, Brian C. Schaefer, D. Brown, Gordon, Dambuza, Ivy M., Lionakis, Michail S., Vasileios Oikonomou, Yoichiro Iwakura, Drummond, Rebecca A., Bing Zhai, Brown, Gordon D, Sergio A. Lira, Naglik, Julian Richard; id_orcid, Filler, Scott G., Rebecca A. Drummond, Schaefer, Brian C, Lira, Sergio A, Gordon D. Brown, Bernhard Hube, Hube, Bernhard, D. Mayer-Barber, Katrin, Swamydas, Muthulekha, Dambuza, Ivy M, A. Lira, Sergio, Mayer-barber, Katrin D., Scott G. Filler, Ivy M. Dambuza, Michail S. Lionakis, Hohl, Tobias M, Brown, Gordon D., Filler, Scott G, G. Filler, Scott, M. Hohl, Tobias, Julian R. Naglik, Drummond, Rebecca A, Lionakis, Michail S, Bohrer, Andrea C., C. Schaefer, Brian, Bohrer, Andrea C, Iwakura, Yoichir, Mayer-Barber, Katrin D, Hohl, Tobias M., S. Lionakis, Michail, Iwakura, Yoichiro, Andrea C. Bohrer   +53 more
core   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.

PLoS Pathogens
Fungal infections have emerged as a major concern among immunocompromised patients, causing approximately 2 million deaths each year worldwide. However, the regulatory mechanisms underlying antifungal immunity remain elusive and require further ...
Guimin Zhao, Yanqi Li, Tian Chen, Feng Liu, Yi Zheng, Bingyu Liu, Wei Zhao, Xiaopeng Qi, Wanwei Sun, Chengjiang Gao   +9 more
doaj   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Antifungal Innate Immunity

International audienceDespite being common inhabitants of human barrier surfaces (skin, oral cavity, gut, lungs, vagina), diseases caused by fungi are rare owing to their surveillance by and sentinel function of human innate immune system.
Wong, Sarah Sze Wah, Aimanianda, Vishukumar, Dellière, Sarah, Lepas, Mathieu   +3 more
core   +1 more source