Results 81 to 90 of about 502,199 (230)

Innate Antifungal Immunity: The Key Role of Phagocytes

, 2011
Fungal diseases have emerged as significant causes of morbidity and mortality, particularly in immune-compromised individuals, prompting greater interest in understanding the mechanisms of host resistance to these pathogens.
Gordon D. Brown
core   +1 more source

Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. [PDF]

, 2007
BACKGROUND\ud \ud Naturally acquired malaria immunity has many determinants and, in the absence of immunological markers of protection, studies assessing malaria incidence through clinical endpoints remain an approach to defining immunity acquisition. We
Schellenberg, David, Penelope Vountasou, Vountasou Penelope, Alonso Pedro L, Kahigwa, E., Schellenberg David, Aponte, John J., Clara Menendez, Marcel Tanner, Vountasou, Penelope, Hassan Mshinda, Mshinda Hassan, John J Aponte, Pedro L Alonso, Mshinda, Hassan, Tanner, Marcel, Aponte John J, Alonso, Pedro, Vountasou, P., David Schellenberg, Kahigwa, Elizeus, Elizeus Kahigwa, Aponte, John J, Menendez Clara, Tanner Marcel, Menendez, Clara, Alonso, Pedro L, Kahigwa Elizeus   +27 more
core   +2 more sources

A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris

Angewandte Chemie, EarlyView.
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger   +8 more
wiley   +2 more sources

Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans

mSphere
Myeloid phagocytes are essential for antifungal immunity against pulmonary Aspergillus fumigatus and systemic Candida albicans infections. However, the molecular mechanisms underlying fungal clearance by phagocytes remain incompletely understood. In this
Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl   +3 more
doaj   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Antifungal Secondary Metabolites Against Blast Fungus Magnaporthe oryzae

, 2022
Magnaporthe oryzae is one of the most destructive fungal pathogen causing blast diseases in at least 50 grass species including wheat and rice. Although there has been comprehensive study on the fungicidal control of blast diseases, the development of ...
Islam, Tofazzal, Chakraborty, Moutoshi
core   +1 more source

Rethinking the immune recognition of cell walls in human fungal pathogens: Mechanisms, controversies and translational significance

Virulence
Fungal cell wall polysaccharides – such as β-glucans, chitin, and mannans – are key immunogenic structures recognized by Toll-like receptors and C-type lectin receptors on innate immune cells, initiating phagocytosis, cytokine production, and antigen ...
Rong Wang, Xiaoyu Peng, Wenqing Liu, Zhangyong Song, Hong Yu   +4 more
doaj   +1 more source

Innate receptors and IL-17 in the immune response against human pathogenic fungi

Revista de la Facultad de Ciencias Médicas de Córdoba, 2018
In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression ...
María Soledad Miró, Cecilia Vigezzi, Emilse Rodriguez, Paula Alejandra Icely, Juan Pablo Caeiro, Fernando Oscar Riera, Diana Teresa Masih, Claudia Elena Sotomayor   +7 more
doaj   +1 more source

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

Antifungal compounds in Geraldton waxflower tissues

, 2003
Geraldton waxflower is the most economically important native Australian cut flower export. Infection of waxflower by Botrytis cinerea can lead to unacceptable levels of flower abscission after harvest.
Khambay, BPS, Khambay, B. P. S., Terry, LA, Joyce, DC, Terry, L. A., Joyce, D. C.   +5 more
core   +1 more source