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Antifungal Prophylaxis in Bone Marrow Transplantation
Clinical Infectious Diseases, 1990Deep fungal infection in recipients of bone marrow transplants remains a significant cause of morbidity and mortality. Prolonged neutropenia is the major factor predisposing patients to invasive fungal disease. Candida and Aspergillus species remain the two most common pathogens.
S T, Milliken, R L, Powles
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Febrile neutropenia: antifungal prophylaxis
International Journal of Antimicrobial Agents, 2000Despite being widely practised there is little or no evidence to support the use of antifungal prophylaxis in febrile nuetropenic patients. With the greater recognition of risk factor, the increasing readiness to use imaging techniques such as the high-resolution CT scan and new methods for detecting fungi such as Aspergillus galactomannan on the one ...
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Antifungal Prophylaxis in Lung Transplant Recipients
Transplantation, 2016Invasive fungal infection remains a serious postoperative complication in lung transplant recipients and is associated with significant morbidity and mortality. Although most lung transplant centers use antifungal prophylaxis, consensus on the strategy, choice of antifungal agent(s), route of administration, and duration of prophylaxis have not been ...
Twisha S, Patel +3 more
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Antifungal Prophylaxis in Bone Marrow Transplant
Annals of Pharmacotherapy, 1995The benefits of fungal prophylaxis with fluconazole in BMT patients appear to outweigh the risks of a possible increase in colonization and infection by C. krusei or T. glabrata. Disseminated fungal infections caused by C. tropicalis and C. albicans have a 38.8% mortality rate, and these infections may be prevented by the prophylactic use of ...
H H, Lam, B L, Althaus
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Targeted Antifungal Prophylaxis in Heart Transplant Recipients
Transplantation, 2013Antifungal prophylaxis after heart transplantation is usually targeted to high-risk recipients, but the duration is normally fixed and empirical. Our purpose was to assess the efficacy of a personalized prophylactic approach based on the duration of the risk factors.In a prospective cohort, from 2003 to 2010, prophylaxis was only administered to ...
Muñoz, Patricia +6 more
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Novel approaches to antifungal prophylaxis
Expert Opinion on Investigational Drugs, 2004Antifungal prophylaxis represents a significant advance in the management of patients at risk from fungal infections in a variety of settings. Identification of patients at the highest risk and the utilisation of safe and effective drugs maximises the benefits of prophylaxis.
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Antifungal Prophylaxis in Lung Transplantation
Seminars in Respiratory and Critical Care Medicine, 2011Fungal infections are among the most serious complications of lung transplantation. The 1-year cumulative incidence of invasive fungal infections in lung transplant recipients is 6 to 10%, which is higher than most other solid organ transplant recipients. Aspergillus spp.
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Antifungal prophylaxis in neutropenic patients
International Journal of Antimicrobial Agents, 1996Although a number of studies have been published on antifungal prophylaxis in neutropenic and bone marrow transplantation patients, there are a lot of conflicting data. Some of this may be due to a lack of consensus on the definition of fungal disease and the definition of end-points for treatment. The risk factors associated with fungal infection, the
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Antifungal Prophylaxis and Pre-Emptive Therapy
Drugs, 2009In recent years, several reports have underlined the increasing role of fungal infections as a cause of morbidity and mortality in hospitalized non-haematological patients. For this reason, and also in light of the high mortality rate associated with these infections, chemoprophylaxis has been advocated for surgical patients hospitalized in intensive ...
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Antifungal prophylaxis in solid organ transplant recipients
Expert Review of Anti-infective Therapy, 2011Solid organ transplantation is life saving for thousands of patients worldwide with end-stage organ failure, but post-transplantation invasive fungal infections (IFIs) remain a significant cause of morbidity and mortality. To improve patient outcomes, investigators have explored various strategies of prevention, including the use of antifungal ...
Kyle D, Brizendine +2 more
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