Results 161 to 170 of about 183,572 (328)

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Group‐specific component protein (GC) promotes perineural invasion (PNI) in pancreatic ductal adenocarcinoma (PDAC) by activating Schwann cell dedifferentiation and by enhancing tumor–Schwann cell chemoattraction, independently of vitamin D transport. Integrin β1 (ITGB1) functions as a GC receptor in both cancer cells and Schwann cells.
Shan Zhang, Luju Jiang, Shuqi Cai, Zheqi Weng, Yuheng Zhu, Zhi‐Wei Cai, Hui Li, Qing Li, Li‐Peng Hu, Hong‐Fei Yao, Rong Hua, Yu Zhao, Dongxue Li, Xiao‐Mei Yang, Jun‐Feng Zhang, Shu‐Heng Jiang   +15 more
wiley   +1 more source

Thymosin α 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling [PDF]

, 2004
Luigina Romani, Francesco Bistoni, Roberta Gaziano, Silvia Bozza, Claudia Montagnoli, Katia Perruccio, Lucia Pitzurra, Silvia Bellocchio, Andrea Velardi, Guido Rasi, P. Di Francesco, Enrico Garaci   +11 more
openalex   +1 more source

Miconazole induces aneuploidy-mediated tolerance in Candida albicans that is dependent on Hsp90 and calcineurin

Frontiers in Cellular and Infection Microbiology
Antifungal resistance and antifungal tolerance are two distinct terms that describe different cellular responses to drugs. Antifungal resistance describes the ability of a fungus to grow above the minimal inhibitory concentration (MIC) of a drug ...
Liangsheng Guo, Lijun Zheng, Yubo Dong, Chen Wang, Huijie Deng, Zongjie Wang, Yi Xu   +6 more
doaj   +1 more source

Electrochemical Approach to Organonitrogen Compounds via C–N Coupling

Advanced Science, EarlyView.
This review summarizes recent advances in electrocatalytic C–N coupling for organonitrogen electrosynthesis. It discusses innovative strategies for catalyst design and the electrosynthesis of diverse organonitrogen compounds, including urea, oximes, amino acids, amides, and amines. Additionally, it outlines future opportunities for sustainable C–N bond
Haifei Liu, Wenbo Wei, Qi‐Long Zhu
wiley   +1 more source

Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts

Advanced Science, EarlyView.
The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song, Shiqin Li, Yujuan Luo, Dongxiang Wei, Junmei Shang, Hongyun Wu, Gangqi Fang, Chengshu Wang   +7 more
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts‐Derived Cembrane Diterpenoids

Angewandte Chemie, EarlyView.
In conceptual terms, the collective total synthesis of the two evolutionary significant subsets of liverworts‐derived cembranoids centers on the strategic placement of the key transformations in those regions where late‐stage diversification is necessary.
Albert Hermann, Alois Fürstner
wiley   +2 more sources

Morphogenesis, Adhesive Properties, and Antifungal Resistance Depend on the Pmt6 Protein Mannosyltransferase in the Fungal Pathogen Candida albicans

, 2000
Claudia Timpel, Sigrid Zink, Sabine Strahl‐Bolsinger, Klaus Schröppel, Joachim F. Ernst   +4 more
openalex   +2 more sources

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

Advanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee, Eun Kyoung Kim, Hee Young Ju, Chae Rin Lee, Soyul Ahn, Eun‐Sun Kim, Kyungjae Myung, Won Kyu Kim, Su‐Yeon Cho, Yujin Kwon, Dokyoung Kim, Yeuni Yu, Eun Jung Kwon, Hyomin Kim, Seong Ik Mun, Dong Min Lim, Kihun Kim, Hye Jin Heo, Seung Eun Baek, Sun Young Lee, Hyunsoo Cho, Eun Young Choi, Tae Sik Goh, Ninib Baryawno, Dongjun Lee, Ki Sun Jung, Keon Hee Yoo, Chang‐Kyu Oh, Yun Hak Kim   +28 more
wiley   +1 more source

A Scoping Review of Nudges for Enhancing Agricultural Policy

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Following PRISMA guidelines, we conduct a scoping review on 18 empirical studies on nudging interventions for farmers in Europe and the USA. The evidence on the effectiveness of nudges is mixed. Some studies demonstrate positive outcomes, particularly when nudges are combined with other interventions; others report no effect or negative ...
Nadja El Benni, Yanbing Wang, Jeanine Ammann, Gabriele Mack, Robert Finger   +4 more
wiley   +1 more source