Results 311 to 320 of about 183,572 (328)

Update on antifungal resistance

Trends in Microbiology, 1997
Overuse of antifungal agents has resulted in the selection of naturally resistant Candida species, as well as expression of resistance from previously susceptible species resulting from genetic mutations and/or selection of resistant subpopulations.
Michael E. Klepser, Michael A. Pfaller, Erika J. Ernst   +2 more
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Antifungal Drug Resistance in Aspergillus

Journal of Infection, 2000
This article overviews the emerging problem of antifungaldrug resistance in Aspergillus. Fluconazole and ketocona-zole (KCZ) are inactive against Aspergillus. Validation oftesting procedures for the detection of itraconazole (ITZ)resistance in Aspergillus fumigatusin 19971,2were furthervalidated with posaconazole (SCH-56592)3,4and voricona-zole (VCZ)5 ...
J. Mosquera, Nicola M. Sayers, Caroline B. Moore, David W. Denning, David W. Denning, John W. Slaven   +5 more
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Antifungal resistance in mucorales

International Journal of Antimicrobial Agents, 2017
The order Mucorales, which includes the agents of mucormycosis, comprises a large number of species. These fungi are characterised by high-level resistance to most currently available antifungal drugs. Standardised antifungal susceptibility testing methods are now available, allowing a better understanding of the in vitro activity of antifungal drugs ...
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Emerging Issues in Antifungal Resistance

Infectious Disease Clinics of North America, 2020
Invasive fungal diseases continue to cause substantial mortality in the enlarging immunocompromised population. It is fortunate that the field has moved past amphotericin B deoxycholate as the only available antifungal drug but despite new classes of antifungal agents both primary and secondary drug resistance in molds and yeasts abound.
John R. Perfect, Mahmoud A. Ghannoum
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Antifungal Resistance Mechanisms in Dermatophytes

Mycopathologia, 2008
Although fungi do not cause outbreaks or pandemics, the incidence of severe systemic fungal infections has increased significantly, mainly because of the explosive growth in the number of patients with compromised immune system. Thus, drug resistance in pathogenic fungi, including dermatophytes, is gaining importance.
Antonio Rossi, Nilce Maria Martinez-Rossi, Nalu T. A. Peres   +2 more
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Antifungal Drugs and Resistance

1995
From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
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Outwitting Multidrug Resistance to Antifungals

Science, 2008
The economic cost of fungal infection and its mortality associated with multidrug resistance remain unacceptably high. Recent understanding of the transcriptional regulation of plasma membrane efflux pumps of modest specificity provides new avenues for the development of broad-spectrum fungicides.
André Goffeau, Brian C. Monk
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Clinical relevance of resistance to antifungals

International Journal of Antimicrobial Agents, 2008
The standardization of antifungal sensitivity tests represents a huge advance in the detection of antifungal drug resistance. Thus, the reference methods of the European Committee on Antibiotic Susceptibility Testing and the Clinical Laboratory Standards Institute have proven capable of detecting strains of yeasts and filamentous fungi with high ...
Manuel Cuenca-Estrella, Isabel Cuesta, Emilia Mellado, Laura Alcazar-Fuoli, Araceli Monzón, Ana Alastruey-Izquierdo, Juan L. Rodriguez-Tudela   +6 more
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Resistance to Antifungal Drugs

2003
Abstract Fungal infections caused by fungal pathogens remain quite common in immunocompromised hosts, especially in HIV-infected individuals, and in patients given immunosuppressive drugs or broad-spectrum antibiotics. Candida spp. represent the major group of yeast species recovered from these infected individuals; however, other yeasts
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Resistance to Antifungal Agents

2007
1 Introduction 2 Definitions of Resistance 3 Detection of Resistance in Vitro 4 Correlation Between in Vitro and Clinical Resistance 5 Mechanisms of Antifungal Resistance 6 Conclusion and Future Directions Keywords: resistance to antifungal agents; field of antifungal therapy-enjoying its most dynamic era; definitions ...
John H. Rex, John H. Rex, Beth A. Arthington-Skaggs   +2 more
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