Results 131 to 140 of about 29,441 (240)

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

Microfluidic and MEMS-Based Biosensing Platforms for Fungal Respiratory Infections in Immunocompromised Patients: Toward Rapid, Specific, and Minimally Invasive Diagnosis. [PDF]

Biosensors (Basel)
Georgakopoulou VE, Pitiriga VC.
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems. [PDF]

Can J Infect Dis Med Microbiol
Pourghasem M, Tabatabaii SA, Modarresi SZ, Jafari Nodoushan A, Fadavi N, Soflaee M, Hosseini Vajari A, Khazaii F, Shahhosseini B, Fakhimi Derakhshan K, Sadat Mansouri S.   +10 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Successful salvage treatment of <i>Mucor nidicola</i> and <i>Aspergillus calidoustus</i> co-infection with oral encochleated amphotericin B (MAT2203) in a pediatric patient with acute myeloid leukemia. [PDF]

Med Mycol Case Rep
Ouellette CP, Ardura MI, Gibas C, Wiederhold N, Song E.   +4 more
europepmc   +1 more source

Image‐Derived Volumetry During Forced Expiration Using a 3D Fermat Looped, Orthogonally Encoded Trajectory

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To enable MRI‐based nongated 3D depiction of forced expiration with both high spatio‐temporal resolution and fidelity of lung dynamics. Methods An undersampled 3D Fermat looped, orthogonally encoded trajectory (FLORET) was optimized for nonsegmented dynamic acquisitions during forced expiration and a corresponding model‐based ...
Sebastian Scheidel, Viktor Hartung, Matthias Stephan Anders, Corona Metz, Herbert Köstler, Simon Veldhoen, Tobias Wech   +6 more
wiley   +1 more source

Candida urinary tract infections, antifungal susceptibility and factors associated with candiduria among pregnant women seeking antenatal care at Murang'a County Referral Hospital, Kenya. [PDF]

BMC Pregnancy Childbirth
Ndungu C, Soi EN, Kamau MN, Musyoki AM.
europepmc   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

In Vitro Antifungal Drug Susceptibility of Feline Sporothrix schenckii Complex Isolates, Thailand, 2023-2025. [PDF]

Emerg Infect Dis
Yurayart C, Yingchanakiat K, Thongbai A, Limsivilai O, Assawarachan SN, Jaroensong T, Sattasathuchana P.   +6 more
europepmc   +1 more source