Results 11 to 20 of about 2,540,577 (239)

Innovation in antifungal therapy [PDF]

EMBO Molecular Medicine
With a steady increase in the number of at-risk patients, invasive fungal infections now represent a significant public health problem. These infections, caused by major pathogens such as Aspergillus, Candida, Cryptococcus, and Pneumocystis, affect ...
Sarah Dellière, Nicolas Papon
doaj   +2 more sources

Chronic Invasive Fungal Rhinosinusitis Managed With Surgical Debridement and Topical Amphotericin B Without Systemic Antifungal Therapy: A Report of Two Cases [PDF]

Journal of Rhinology
Chronic invasive fungal rhinosinusitis (CIFR) is a rare subtype of invasive fungal rhinosinusitis characterized by a slow clinical course and histopathologic evidence of tissue invasion.
Do Hun Kim, Yanggyun Lee, Bomi Kim, Seong Kook Park   +3 more
doaj   +2 more sources

Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™ [PDF]

, 2011
Background: Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70–90%) in immunocompromised patients.
M N V Ravi Kumar, Sharp Andrew, Jagdishbhai L. Italia, Carter, Katharine C., Carter Katharine C., Kumar, M. N V Ravi, Kumar M. N. V. Ravi, Jagdishbhai L Italia, Italia Jagdishbhai L., Italia, Jagdishbhai L., Katharine C. Carter, M. N. V. Ravi Kumar, Andrew Sharp, Italia, Jagdishbhai L, Kumar, M N V Ravi, Warn, Peter, Warn Peter, Sharp, Andrew, Carter, Katharine C, Katharine C Carter, Peter Warn   +20 more
core   +5 more sources

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target [PDF]

, 2013
The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor for the synthesis of chitin, an essential component of the fungal cell wall.
Hurtado-Guerrero, Ramon, Ibrahim, Adel F. M., van Aalten, D.M.F., van Aalten, Daan M. F., Ferguson, Michael A. J.; id_orcid, Urbaniak, Michael D., Jin, Cheng, Jin, Cheng Jun, Raimi, Olawale G., Urbaniak, Mick, Ferguson, Michael A. J., Du, Ting, Fang, Wenxia   +12 more
core   +5 more sources

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source

Exploring hidden dimensions of soil fungal biodiversity: A simple technique to detect soil fungi resistant to antifungal compounds [PDF]

, 2010
Soils are known to be ultimate and complex reservoirs of microbial diversity. The complex dimensions of bacterial and fungal diversity in tropical soils and microbial community dynamics are underexplored.
Sonashia Velho-Pereira, Nandkumar M. Kamat   +1 more
core   +1 more source

Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. [PDF]

, 2014
Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care but may not be suitable for resource-poor settings.
Sharp, Andrew D, Andrew D. Sharp, Julie A. Schwartz, Gregson, Lea, Howard, Susan J, Goodwin, Joanne, Susan J. Howard, Bill Moser, John R. Perfect, Müller, W, Sharp, AD, Joanne Goodwin, Moser, Bill, Walker, Catherine, Hope, William W, Lea Gregson, Hope, WW, Perfect, John R, Joanne Livermore, Werner Müller, Schwartz, JA, William W. Hope, Felton, Timothy; id_orcid, Timothy Felton, Catherine Walker, Livermore, J, Schwartz, Julie A, Gregson, L, Goodwin, J, Harrison, Thomas S, Livermore, Joanne, Howard, SJ, Felton, T, Harrison, TS, Walker, C, Perfect, JR, Thomas S. Harrison, Müller, Werner; id_orcid, Moser, B   +38 more
core   +1 more source

Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model [PDF]

, 2011
In conventional MIC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations.
Thomas J. Walsh, Emmanuel Roilides, Aristea Velegraki, Walsh, Thomas, Zerva, Loukia, Meletiadis, Joseph, Joseph Meletiadis, Roilides, Emmanuel, Rafal Al-Saigh, Velegraki, Aristea, Loukia Zerva, Al Saigh, Rafal   +11 more
core   +1 more source

Species Distribution and in Vitro Antifungal Susceptibility of Oral Yeast Isolates from Tanzanian HIV-Infected Patients With Primary and Recurrent Oropharyngeal Candidiasis. [PDF]

, 2008
\ud In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis.
Rijs Antonius JMM, Mugusi Ferdinand, Simon Elison NM, van der Ven, A.J., Rijs, A.J.M.M, Verweij, P.E., Verweij, P.E, Simon, Elison N M, Matee, Mecky I N, Palenstein Helderman, W.H. van, Moshi, M.J, Van Palenstein Helderman, W.H, Moshi, Mainen J, Rijs, Antonius J M M, Hamza, O.J.M., Wim Helderman, Frans HM Mikx, Simon, E.N.M., Verweij, Paul E, Ferdinand Mugusi, Mugusi, Ferdinand, Hamza, Omar J M, van der Ven André JAM, Antonius JMM Rijs, Mikx, F.H.M., Rijs, A.J.M.M., Elison NM Simon, Ven, A.J.A.M. van der, Mikx Frans HM, Matee Mecky IN, Matee, M.I.N, Simon, E.N., Verweij Paul E, Paul E Verweij, Helderman, W.H.P., Moshi, M.J., Moshi Mainen J, Simon, E.N.M, Helderman, Wim H van Palenstein, André JAM van der Ven, Mecky IN Matee, Mikx, Frans H M, Omar JM Hamza, Mugusi, F., van der Ven, André J A M, Mainen J Moshi, Matee, M.I.N., Mikx, F.H.M, Van der Ven, A.J.A.M, Hamza, O.J.M, Hamza Omar JM, Helderman Wim   +51 more
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A CONTRIBUTION TO THE STUDY OF BIOCONTROL AGENTS APITHERAPY AND OTHER POTENTIAL ALTERNATIVES TO ANTIBIOTICS [PDF]

, 2011
We are living in what has been termed the “post antibiotics era’ where the emergence of multidrug-resistant pathogen strains is rapidly growing and where the introduction of and the development of novel antimicrobial agents, which are effective against ...
ALNAIMAT, SULAIMAN
core   +6 more sources