Results 31 to 40 of about 2,540,577 (239)

Fungal biofilm resistance [PDF]

, 2012
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Ramage, Gordon, Williams, Craig, Rajendran, Ranjith, Ranjith Rajendran, Gordon Ramage, Leighann Sherry, Sherry, Leighann, Craig Williams   +7 more
core   +1 more source

Antifungal therapy did not improve outcomes including 30-day all-cause mortality in patients suffering community-acquired perforated peptic ulcer-associated peritonitis with Candida species isolated from their peritoneal fluid

Journal of Microbiology, Immunology and Infection, 2017
Background/purpose: Although patients suffering community-acquired perforated peptic ulcer (PPU)-associated peritonitis with Candida species isolated from their peritoneal fluid have higher chances of mortality and experiencing a complicated ...
Wei-Sin Li, Chen-Hsiang Lee, Jien-Wei Liu   +2 more
doaj   +1 more source

Complications of hematopoietic stem transplantation: Fungal infections

Hematology/Oncology and Stem Cell Therapy, 2017
Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk of invasive fungal infections, especially during the early neutropenic phase and severe graft- versus-host disease.
Ali S. Omrani, Reem S. Almaghrabi
doaj   +1 more source

Impact of ITS-Based Sequencing on Antifungal Treatment of Patients with Suspected Invasive Fungal Infections

Journal of Fungi, 2020
Molecular techniques including the sequencing of fungal-specific DNA targets are increasingly used in the diagnosis of suspected invasive fungal infections.
Sara Guenter, Gregor Gorkiewicz, Bettina Halwachs, Karl Kashofer, Andrea Thueringer, Phillip Wurm, Ines Zollner-Schwetz, Thomas Valentin, Juergen Prattes, Stefanie Wunsch, Elisabeth Ullrich, Christoph Zurl, Martin Hoenigl, Robert Krause   +13 more
doaj   +1 more source

Use of volatile fingerprints for rapid screening of antifungal agents for efficacy against dermatophyte Trichophyton species [PDF]

, 2010
The potential of using an electronic nose (E-nose) as a rapid technique for screening the responses of dermatophytes to antifungal agents was studied.
Adriaans, B, Barr, Hugh, Magan, Naresh, Sahgal, N, Sahgal, Natasha, Barr, H, Magan, N, Naraghi, Kamran, Adriaans, Beverley, Naraghi, K   +9 more
core   +1 more source

Antifungal resistance in dermatology

Indian Journal of Dermatology, 2018
Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors.
Varadraj Pai, Ajantha Ganavalli, Naveen Narayanshetty Kikkeri   +2 more
doaj   +1 more source

Case report: nanopore targeted sequencing in the diagnosis of invasive pulmonary Aspergillus infection in a patient with acute promyelocytic leukemia

Hematology, 2023
Invasive pulmonary aspergillosis (IPA) is an infectious disease with a high mortality rate due to diagnostic difficulties associated with the lack of a typical clinical presentation and the inadequacy of the available laboratory testing methods. Nanopore
Qiuxia Huang, Yaohui Wu, Xuan Lu, Linghui Xia   +3 more
doaj   +1 more source

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Lehrnbecher, Thomas, Thomas eLehrnbecher, Schmidt, Stanislaw, Thomas eKlingebiel, Tramsen, Lars, Lars eTramsen, Klingebiel, Thomas, Stanislaw eSchmidt   +7 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source