Results 41 to 50 of about 31,747 (264)

Combined Toxicity of Microplastics and Antimicrobials on Animals: A Review

Antibiotics
Background/Objectives: Microplastics are ubiquitous pollutants that pose physical toxicity and serve as vectors for antimicrobial agents, altering their bioavailability and toxicity.
Kuok Ho Daniel Tang
doaj   +1 more source

Novel Cell Wall Antifungals Reveal a Special Synergistic Activity in pbr1 Mutants Resistant to the Glucan Synthesis Antifungals Papulacandins and Echinocandins

Frontiers in Microbiology, 2019
A series of 4-(arylmethylene)-3-isochromanones have been prepared with base-catalyzed Knoevenagel condensation starting from 3-isochromanone and aromatic aldehydes.
Rodrigo Berzaghi, Attila Agócs, María A. Curto, Gergely Gulyás-Fekete, Béla Kocsis, Juan C. Ribas, Tamás Lóránd   +6 more
doaj   +1 more source

Biomimetic Vascular Scaffold with Seamless Electrospun Aligned Nanofiber Conduit and 3D‐Printed Coil Reinforcement

Advanced Healthcare Materials, EarlyView.
We introduce a new fabrication method that overcomes the current limitation of tubular gap electrospinning. We successfully fabricated a seamless hollow tube with fibers aligned along the longitudinal axis in diameters as small as 300 µm, and then reinforced it using 4‐axis 3D printing.
Seyed Aliakbar Hosseini Toopghara, Young‐Ook Hwang, In A Kim, Che‐I Hyun, Hochung Ryu, Won‐Jae Kim, Jeong‐Tae Koh, Hyun‐Pil Lim, Jin‐Ho Kang, Sang‐Won Park   +9 more
wiley   +1 more source

Changes in nomenclature, virulence factors, and antifungal resistance of the genus Candida

Frontiers in Fungal Biology
Some Candida species of clinical interest have undergone recent nomenclature changes. These yeasts have a high capacity to adhere to and infect host tissues, driven by their virulence factors, as well as by the incidence of antifungal resistance.
Maria Alyce Albuquerque Fernandes, Maria Alyce Albuquerque Fernandes, Francisca Lidiane Linhares de Aguiar, Maria Gleiciane Soares Coutinho, Erika Helena Salles de Brito, Camila Gomes Virginio Coelho, Raquel Oliveira dos Santos Fontenelle   +6 more
doaj   +1 more source

Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides

Frontiers in Microbiology, 2017
Oligopeptides incorporating N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0 ...
Marta Schielmann, Piotr Szweda, Katarzyna Gucwa, Marcin Kawczyński, Maria J. Milewska, Dorota Martynow, Joachim Morschhäuser, Sławomir Milewski   +7 more
doaj   +1 more source

Antifungal Activity of Chitosan against Histoplasma capsulatum in Planktonic and Biofilm Forms: A Therapeutic Strategy in the Future?

Journal of Fungi, 2023
Histoplasmosis is a respiratory disease caused by Histoplasma capsulatum, a dimorphic fungus, with high mortality and morbidity rates, especially in immunocompromised patients.
Raimunda Sâmia Nogueira Brilhante, Anderson da Cunha Costa, Jacó Ricarte Lima de Mesquita, Gessica dos Santos Araújo, Rosemeyre Souza Freire, João Victor Serra Nunes, Augusto Feynman Dias Nobre, Mirele Rodrigues Fernandes, Marcos Fábio Gadelha Rocha, Waldemiro de Aquino Pereira Neto, Thomas Crouzier, Ulrike Schimpf, Rodrigo Silveira Viera   +12 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Molecular identification and antifungal susceptibility patterns of dermatophytes isolated from companion animals with clinical symptoms of dermatophytosis

Journal of Veterinary Research, 2021
Dermatophytosis is a common skin disease in cats and dogs caused by Microsporum and Trichophyton fungi. Species identification and knowledge of their antifungal susceptibility are therapeutically and epidemiologically important.
Katiraee Farzad, Kouchak Kosari Yasaman, Soltani Minoo, Shokri Hojjatollah, Hassan Minooieanhaghighi Mohammad   +4 more
doaj   +1 more source

Targeting DNA Topoisomerase II in Antifungal Chemotherapy

Molecules, 2022
Topoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to ...
Kavya Kondaka, Iwona Gabriel
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source