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2020
In vertebrates, immunoglobulins (Igs), commonly known as antibodies, play an integral role in the armamentarium of immune defense against various pathogens. After an antigenic challenge, antibodies are secreted by differentiated B cells called plasma cells.
Maksymilian Chruszcz +2 more
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In vertebrates, immunoglobulins (Igs), commonly known as antibodies, play an integral role in the armamentarium of immune defense against various pathogens. After an antigenic challenge, antibodies are secreted by differentiated B cells called plasma cells.
Maksymilian Chruszcz +2 more
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Simulations that capture antigen–antibody complexity
Nature Computational Science, 2022Abstract: Antigen-antibody prediction remains a complex computational challenge. Simulations with the new Absolut! package provide novel insights into the models and datasets tackling this problem.
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Australia Antigen–Antibody Complexes
Nature, 1970BLUMBERG and his colleagues have published data on the relation of Australia antigen, Au(1), to hepatitis1,2. While existing antisera, either of human or rabbit sources3, frequently can be used to detect this antigen in patients with hepatitis by either immunodiffusion4 or complement fixation5 it is probable that the antigen is undetectable in some ...
Irving Millman +3 more
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Degenerate interfaces in antigen-antibody complexes
Journal of Molecular Biology, 2001In most of the work dealing with the analysis of protein-protein interfaces, a single X-ray structure is available or selected, and implicitly it is assumed that this structure corresponds to the optimal complex for this pair of proteins. However, we have found a degenerate interface in a high-affinity antibody-antigen complex: the two independent ...
Decanniere, Klaas +5 more
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On the composition of insoluble antigen-antibody complexes
Journal of Theoretical Biology, 1968Abstract A relationship is established between the behavior of precipitin curves in the far antibody and antigen excess regions and the composition of certain soluble and insoluble antigen-antibody complexes. The primary assumption made is that antigen-antibody reactions proceed according to the principle of mass action.
Michael T. Palmiter, Frederick Aladjem
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Modulation of Antigen‐Antibody Complexations by Immunoglobulins
Scandinavian Journal of Immunology, 1995In this investigation, the modulating effects of non‐immune human IgG and rheumatoid factors (RFs) on antigen‐antibody complexations were studied. Non‐immune human IgG, as well as RF, were found to inhibit the binding of antigen to specific antibodies of both human and rabbit origin.
J. Bjorklund +3 more
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Circulating Antigen Antibody Complexes in Scabies
Dermatology, 1978Circulating immune complexes measured by the binding of Clq in 29 scabies patients and 52 control individuals have been found increased in the treated scabies patient.
J. Salmon, D. Van Neste
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Antigen‐Antibody Complexes in Hemophilia
Scandinavian Journal of Haematology, 1984Antigen‐antibody complexes have been found by several groups of investigators in patients with hemophilia. The amount of circulating immune complexes (CIC) has varied with the assay method, the largest amount has been found with the Staph binding assay and the smallest with the Raji cell method. We have correlated the level of immune complexes detected
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Immunoregulatory effects of a covalent antigen–antibody complex
Nature, 1979It is becoming increasingly clear that any specific immune response must be subject to a control mechanism of the same order of specificity. The basis of such specificity in control almost certainly lies in the antibodies themselves, whether free or cell bound.
Taylor, R B, Tite, J P, Manzo, C
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