Results 231 to 240 of about 1,301,436 (306)

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Preexisting IgG forms immune complexes and links local thermal reactogenicity with immunogenicity in influenza vaccination

Hirsiger JR, Scarascia S, Recher M, Bantug G, Berger CT.   +4 more
europepmc   +1 more source

Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes. [PDF]

Proc Natl Acad Sci U S A
Wu NR, Castro KM, Beutler N, Lee WH, Raghavan SSR, Martin GM, Jain M, Agrawal S, Liguori A, Kalyuzhniy O, Skog PD, Terada S, Lai YC, Ndihokubwayo J, Lu D, Eskandarzadeh S, Alavi N, Phelps N, Tingle R, Youhanna JE, Amirzehni S, Rogers TF, Burton DR, Wilson IA, Ward AB, Correia BE, Schief WR.   +26 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Recent Advances, Bottlenecks, and Future Directions in <i>Plasmodium falciparum</i> Vaccine Development. [PDF]

Vaccines (Basel)
Turan G, Boggio MJ, Othman AS, Nnaemeka V, Hill AVS, Salman AM.   +5 more
europepmc   +1 more source

Recent Advances in Lateral Flow Immunoassay for Rapid Diagnosis of Viral Diseases. [PDF]

Transbound Emerg Dis
Ren Q, Wang Y, Ma H, Xie J, Jin J, Tian R, Yu H, Gao X, Chen N.   +8 more
europepmc   +1 more source

Beyond Donor-Specific Antibodies: The Unseen Role of Non-Donor-Specific Anti-human Leukocyte Antigen (HLA) Antibodies in Rejection. [PDF]

Cureus
Kashiv P, Balwani M, Pasari AS, Kute V.
europepmc   +1 more source

Serum Sickness After Cosmetic Botulinum Toxin Type A Injections. [PDF]

Aesthet Surg J Open Forum
DeLuca-Pytell D, Dass K, Audia G, Busuito E.   +3 more
europepmc   +1 more source

Structural insight into the assembly and D antigenicity of polio type 1 stabilized virus-like particles. [PDF]

NPJ Vaccines
Hong Q, Chen T, Han W, Wang S, Lian C, Zhang Y, Ruan L, Wang T, Lin C, Song C, Liu Q, Wang X, Cong Y, Huang Z.   +13 more
europepmc   +1 more source