Results 241 to 250 of about 1,112,551 (312)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Evaluating neoantigen-vaccine responses through mechanistic and model-based frameworks. [PDF]

NPJ Precis Oncol
Ibrahim EIK, Laurén I, Veerman RE, Jönsson S, Ytterberg AJ, Lindqvist A, Mangsbo SM, Friberg LE.   +7 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

NAStructuralDB : structural database to facilitate computational studies of molecular modeling and recognition of proteins with special focus on antibody-antigen interactions. [PDF]

MAbs
Chomicz D, Dudzic P, Wrobel S, Gawlowski T, Demharter S, Spreafico R, Minoux H, Phillips A, Krawczyk K.   +8 more
europepmc   +1 more source

Hapten-Based Cancer Immunotherapy: From Immune Activation to Antitumor Activity. [PDF]

Cells
Richert I, Chalus L, Pinteur B, Bravetti P, Tortorelli C, Alzeeb G, Ghiringhelli F.   +6 more
europepmc   +1 more source

Serum as a surrogate for salivary IgG: comparison of antigen-specific serum and salivary IgG in sheep. [PDF]

Front Immunol
Yeung J, Hannaford R, Wilson T, Ferguson T, Khanum S, McNeilly TN, Janssen PH, Wedlock DN.   +7 more
europepmc   +1 more source

Exploring the Vaccine Adjuvant Effect and Mechanism of <i>Epimedium</i> Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations. [PDF]

Vaccines (Basel)
Tang M, Zhao A, Yang Y, Song Z, Wang S, Ye X, Luo H, Zhao L, Pan J, Zou Q, Sun H, Zeng H.   +11 more
europepmc   +1 more source

One-step cleavage and purification: a bifunctional IdeS-Protein A fusion protein for on-column generation of antibody fragments. [PDF]

MAbs
Zhang T, Liao H, Teng CB, Wang C.
europepmc   +1 more source