Results 61 to 70 of about 1,112,551 (312)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Targeting cancer expressed EGFR with a humanized monoclonal antibody

Scientific Reports
The humanization of mouse monoclonal antibodies targeting tumor antigens allows for the safe and repeated administration of therapeutic antibodies to humans.
Tamara G. Fernandes Costa, Robert Sarnovsky, Jingyu Zhan, Carolyn A. Maslanka, Ifechukwu Obiorah, Di Xia, David FitzGerald, Antonella Antignani   +7 more
doaj   +1 more source

Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation.
Marcus Nascimento Borges, Gil Facina, Ismael Dale Cotrin Guerreiro Silva, Angela Flávia Logullo Waitzberg, Afonso Celso Pinto Nazario   +4 more
doaj   +1 more source

Flow cytometry method for platelet-specific antibody detection by acid treatment through human leukocyte antigen-1 removal

Global Journal of Transfusion Medicine, 2019
Background: Platelet (PLT) transfusion has been a crucial for clinical blood transfusion and bleeding prophylaxis. Identification of antibody against PLT-specific antigen is important for accurately diagnosing posttransfusion purpura, neonatal alloimmune
Qin-Qin Ma, Hui-Jun Zhu, Li Rui-Shu, Fu Min, Lu Ping   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Antibody-antigen complex formation with immobilized immunoglobulins [PDF]

, 1992
We have investigated the complex formation between an immobilized monoclonal antibody and antigens that differ in size about 50-fold. As a model system, we used an iodinated progesterone derivative and a progesterone-horseradish peroxidase conjugate as ...
Se-Hwan Paek, Schramm, Willfried, Willfried Schramm, Paek, Se-Hwan   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

DNA Encoded Biotechnologies for Informative Cancer Diagnostics [PDF]

, 2009
This thesis describes the development of DNA-encoded, multi-parametric, sensing platforms for informative cancer diagnostics. In the first part of this thesis, I will present a technology called “DNA-encoded antibody library (DEAL).” In this approach ...
Kwong, Gabriel Abner
core   +1 more source

Structural insights into chemokine CCL17 recognition by antibody M116

Biochemistry and Biophysics Reports, 2018
The homeostatic chemokine CCL17, also known as thymus and activation regulated chemokine (TARC), has been associated with various diseases such as asthma, idiopathic pulmonary fibrosis, atopic dermatitis and ulcerative colitis. Neutralization of CCL17 by
Alexey Teplyakov, Galina Obmolova, Gary L. Gilliland   +2 more
doaj   +1 more source