Results 61 to 70 of about 7,021,714 (299)

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]

, 1998
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS, Christopher A. O'Callaghan, Philip J.R. Goulder, O'Callaghan, CA, Allen, RL, Anthony Kelleher, Andy K. Sewell, Rowland-Jones, Sarah, Jamie D.K. Wilson, Kelleher, A, Mcmichael, Andrew, Goulder, PJ, Andrew J. McMichael, O'Callaghan, Christopher, Graham S. Ogg, Rachel L. Allen, Rowland-Jones, SL, Callan, MF, Wilson, JD, Sarah L. Rowland-Jones, Margaret F.C. Callan, Sewell, AK, McMichael, AJ   +22 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

THE "DELAYED HYPERSENSITIVITY" INDUCED BY ANTIGEN-ANTIBODY COMPLEXES [PDF]

The Journal of Experimental Medicine, 1958
The "delayed hypersensitive" reactivity induced by antigen-antibody complexes has been studied from the standpoints of the role of such complexes in establishing this state, and the relationship of this state to classical delayed hypersensitivity. It has been shown that the reactivity established by antigen-antibody complexes appears ...
S, RAFFEL, J M, NEWEL
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Targeting cancer expressed EGFR with a humanized monoclonal antibody

Scientific Reports
The humanization of mouse monoclonal antibodies targeting tumor antigens allows for the safe and repeated administration of therapeutic antibodies to humans.
Tamara G. Fernandes Costa, Robert Sarnovsky, Jingyu Zhan, Carolyn A. Maslanka, Ifechukwu Obiorah, Di Xia, David FitzGerald, Antonella Antignani   +7 more
doaj   +1 more source

Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation.
Marcus Nascimento Borges, Gil Facina, Ismael Dale Cotrin Guerreiro Silva, Angela Flávia Logullo Waitzberg, Afonso Celso Pinto Nazario   +4 more
doaj   +1 more source

Flow cytometry method for platelet-specific antibody detection by acid treatment through human leukocyte antigen-1 removal

Global Journal of Transfusion Medicine, 2019
Background: Platelet (PLT) transfusion has been a crucial for clinical blood transfusion and bleeding prophylaxis. Identification of antibody against PLT-specific antigen is important for accurately diagnosing posttransfusion purpura, neonatal alloimmune
Qin-Qin Ma, Hui-Jun Zhu, Li Rui-Shu, Fu Min, Lu Ping   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Development of antibody technology to identify natural killer cell surface antigens in Xenopus Laevis [PDF]

, 1999
Natural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7).
Minter, Ralph
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source