Results 41 to 50 of about 1,112,551 (312)

Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection [PDF]

, 2006
BACKGROUND: Plasmodium falciparum merozoite surface protein (MSP) 3 is an asexual blood-stage malaria vaccine candidate antigen. Sequence polymorphisms divide alleles into 2 major types, but the adaptive and immunological significance of the types has ...
Greenwood, Brian M, Conway, David J, Lloyd, JM, Greenwood, BM, Tetteh, Kevin KA, Conway, DJ, Lloyd, Jennie M, Polley, SD, Bojang, KA, Akpogheneta, Onome J, Tetteh, KK, Bojang, Kalifa A, Polley, Spencer D, Akpogheneta, OJ   +13 more
core   +1 more source

Use of poxvirus display to select antibodies specific for complex membrane antigens

mAbs, 2023
Antibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into ...
Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris, Maurice Zauderer   +21 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

SnugDock: paratope structural optimization during antibody-antigen docking compensates for errors in antibody homology models.

PLoS Computational Biology, 2010
High resolution structures of antibody-antigen complexes are useful for analyzing the binding interface and to make rational choices for antibody engineering.
Aroop Sircar, Jeffrey J Gray
doaj   +1 more source

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

Nature Communications, 2021
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (pAb ...
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward   +31 more
doaj   +1 more source

Structural Features of Antibody-Peptide Recognition

Frontiers in Immunology, 2022
Antibody recognition of antigens is a critical element of adaptive immunity. One key class of antibody-antigen complexes is comprised of antibodies targeting linear epitopes of proteins, which in some cases are conserved elements of viruses and pathogens
Jessica H. Lee, Rui Yin, Rui Yin, Gilad Ofek, Gilad Ofek, Brian G. Pierce, Brian G. Pierce, Brian G. Pierce   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria [PDF]

, 2009
Background Plasmodium falciparum malaria is a complex disease in which genetic and environmental factors influence susceptibility. IgG isotypes are in part genetically controlled, and GM/KM allotypes are believed to be involved in this control.
Thor G Theander, Troye-Blomberg, Marita,, Marita Troye-Blomberg, ElGhazali, Gehad, ElGhazali Gehad, Janardan P Pandey, Giha, Hayder A., Pandey, Janardan P, Giha Hayder A, Iriemenam, Nnaemeka C., Nasr, Amre, Gehad ElGhazali, David Arnot, Giha, Hayder A, Nasr, Amre,, Troye-Blomberg, Marita, Theander, Thor G., Pandey, Janardan P., Berzins, Klavs, Berzins Klavs, Berzins, Klavs,, Hayder A Giha, Nnaemeka C Iriemenam, Theander, Thor G, Theander Thor G, Iriemenam, Nnaemeka C, Troye-Blomberg Marita, Nasr Amre, Klavs Berzins, Iriemenam Nnaemeka C, Arnot, David, Amre Nasr, Arnot David, Pandey Janardan P, Iriemenam, Nnaemeka C.,   +34 more
core   +1 more source

THE "DELAYED HYPERSENSITIVITY" INDUCED BY ANTIGEN-ANTIBODY COMPLEXES [PDF]

The Journal of Experimental Medicine, 1958
The "delayed hypersensitive" reactivity induced by antigen-antibody complexes has been studied from the standpoints of the role of such complexes in establishing this state, and the relationship of this state to classical delayed hypersensitivity. It has been shown that the reactivity established by antigen-antibody complexes appears ...
S, RAFFEL, J M, NEWEL
openaire   +2 more sources