Results 71 to 80 of about 2,402,498 (300)

Genomic Organization, Splice Variants and Expression of CGMl, a CD66-related Member of the Carcinoembryonic Antigen Gene Family [PDF]

, 1993
The tumor marker carcinoembryonic antigen (CEA) belongs to a family of proteins which are composed of one immunogiobulin variable domain and a varying number of immunoglobulin constant-like domains.
Zimmermann, Wolfgang, Grunert, F., Suzanne M. WATT, Watt, S. M., Grunert, Fritz, Watt, Suzanne M., Thompson, J., Fritz GRUNERT, Kuijpers, Taco W., John THOMPSON, Nagel, Gerhard, Thompson, John A., Kuijpers, T. W., Taco W. KUIJPERS, Gerhard NAGEL, Wolfgang ZIMMERMANN, Zimmermann, W., Nagel, G.   +17 more
core   +2 more sources

Antigen-antibody interaction

, 2007
The clonal selection theory of acquired immunity provides a relatively graceful to comprehend explanation for the diversity and specificity of the acquired immune system.
Jason Brownlee (6868694)
core   +1 more source

Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity [PDF]

, 2005
When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they ...
Lambrianides, A, Rahman, A, Anisur Rahman, Isenberg, DA, Mason, LJ, David S Latchman, Lesley J Mason, Manson, JJ, Latchman, DS, Jessica J Manson, David A Isenberg, Joanna D Haley, Haley, JD, Anastasia Lambrianides   +13 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Anaphylactic shock with methylprednisolone, Kounis syndrome and hypersensitivity to corticosteroids: a clinical paradox

Italian Journal of Pediatrics, 2018
Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome.
Nicholas G. Kounis, Ioanna Koniari, George D. Soufras, Emmanouil Chourdakis   +3 more
doaj   +1 more source

Inferring epitopes of a polymorphic antigen amidst broadly cross-reactive antibodies using protein microarrays: a study of OspC proteins of Borrelia burgdorferi. [PDF]

PLoS ONE, 2013
Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming
Elisabeth Baum, Arlo Z Randall, Michael Zeller, Alan G Barbour   +3 more
doaj   +1 more source

Antigen-specific serum antibody responses.

, 2016
NHC flagellin-specific antibody levels in the groups immunized with (A) 40 μg of NHC protein and (B) 20 μg of NHC protein, both compared to levels in the solvent injected control group.
Jos P. M. van Putten (103913), Koen M. Verstappen (787655), Katarzyna A. Radomska (131298), Mahdi M. Vaezirad (3229206), Marc M. S. M. Wösten (37615), Jaap A. Wagenaar (103922)   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant. [PDF]

PLoS ONE, 2013
Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, the ...
Natalie E Stevens, Cara K Fraser, Mohammed Alsharifi, Michael P Brown, Kerrilyn R Diener, John D Hayball   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source