Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Inferring epitopes of a polymorphic antigen amidst broadly cross-reactive antibodies using protein microarrays: a study of OspC proteins of Borrelia burgdorferi. [PDF]
PLoS ONE, 2013 Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming
Elisabeth Baum +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
I. A Theory of Antibody-Antigen Reactions. Part II. The Light-Scattering Properties of an Antigen-Antibody Reaction. III. Light-Scattering Arising from Composition Fluctuations in Multi-Component Systems [PDF]
, 1952 Part I describes a theory of antibody-antigen reactions employing bivalent and univalent antibody molecules and multivalent antigen molecules. All species in a system of this kind are defined by a distribution function which has been derived on the ...
Goldberg, Richard Jay
core +1 more source
An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant. [PDF]
PLoS ONE, 2013 Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, the ...
Natalie E Stevens +5 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes [PDF]
, 2004 Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R. Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology.
Evstigneev, Mykhaylo ; https://orcid.org/ +4 more
core +2 more sources
Chicken serologic response to Salmonella enterica serotype Typhimurium assessed by Elisa
Brazilian Journal of Poultry Science, 2006 This study evaluated two enzyme-linked immunosorbent assays (ELISA) in the detection of chicken serologic response against Salmonella enterica sorotype Typhimurium.
GH Oliveira +2 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Confocal laser scanning microscopy of nanoparticles applied to immunosorbent assays [PDF]
, 2011 The aim of this project was to demonstrate and develop a confocal readout method for fluorescent immunosorbent assays and investigate its potential advantages in comparison to traditional immunoassays.
Ghafari, H
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