Results 111 to 120 of about 3,861,164 (348)

PPE18 and PepA Variations in Mycobacterium tuberculosis Clinical Isolates from Makassar, Indonesia: Challenges for Immune Recognition and Vaccine Development

International Journal of Mycobacteriology
Background: The M72/AS01E tuberculosis vaccine candidate, currently on trial in Indonesia, includes PPE18 (Rv1196) and PepA (Rv0125) as key antigens. Genetic variation in these proteins may affect immune recognition and vaccine efficacy.
Stephanie Cynthia Theorupun, Muhammad Nasrum Massi, Astutiati Nurhasanah, Fadhilah Syamsuri, Mochammad Hatta, Yoeke Dewi Rasita, Najdah Hidayah, Nihayatul Karimah, Doddy Irawan Setyo Utomo   +8 more
doaj   +1 more source

Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance [PDF]

, 2023
Elham Ahmadi, Simon Wang, Mohammad Gouran‐Savadkoohi, Georgia Douvi, Naghmeh Isfahanian, Nicole Tsakiridis, Brent E. Faught, Jean‐Claude Cutz, Monalisa Sur, Satish Chawla, Gregory R. Pond, Gregory R. Steinberg, Ian H. Brown, Theodoros Tsakiridis   +13 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Unveiling reverse vaccinology and immunoinformatics toward Saint Louis encephalitis virus: a ray of hope for vaccine development

Frontiers in Immunology
IntroductionInfectious diseases continue to challenge human health with high incidence and mortality rates worldwide. Notably, the adaptability of RNA viruses, highlighted by outbreaks of SARS, MERS, and COVID-19, emphasizes the timely need for effective
Prasanna Srinivasan Ramalingam, Mahalakshmi Aranganathan, Mahalakshmi Aranganathan, Md Sadique Hussain, Sujatha Elangovan, Gayathri Chellasamy, Purushothaman Balakrishnan, Janaki Ramaiah Mekala, Kyusik Yun, Sivakumar Arumugam   +9 more
doaj   +1 more source

The Trypomastigote Small Surface Antigen from Trypanosoma cruzi Improves Treatment Evaluation and Diagnosis in Pediatric Chagas Disease [PDF]

, 2017
Virginia Balouz, Luciano J. Melli, Romina Volcovich, Guillermo Moscatelli, Samanta Moroni, Nicolás González, Griselda Ballering, Margarita Bisio, Andrés E. Ciocchini, Carlos A. Buscaglia, Jaime Altcheh   +10 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Human chimeric antigen receptor macrophages for cancer immunotherapy

Nature Biotechnology, 2020
M. Klichinsky, M. Ruella, O. Shestova, X. Lu, Andrew Best, Martha E. Zeeman, Maggie Schmierer, Konrad Gabrusiewicz, Nicholas R. Anderson, Nicholas E. Petty, K. Cummins, F. Shen, Xinhe Shan, Kimberly Veliz, K. Blouch, Yumi Yashiro‐Ohtani, S. Kenderian, Miriam Y Kim, Roddy S. O’Connor, Stephen R. Wallace, M. Kozlowski, Dylan M. Marchione, Maksim Shestov, B. Garcia, C. June, S. Gill   +25 more
semanticscholar   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Immunological Monitoring in the System of Epidemiological Surveillance of Brucellosis in Siberia

Эпидемиология и вакцинопрофилактика
Relevance. Brucellosis is a particularly dangerous zoonotic infectious disease, characterized by multiple lesions of organs with a high potential for transition to a chronic forms. In recent years a situation on brucellosis remains unstable epidemiologic
N. O. Kiseleva, V. I. Dubrovina, K. M. Korytov, A. B. Pyatidesyatnikova, D. D. Bryukhova, S. V. Balakhonov   +5 more
doaj   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source