Results 101 to 110 of about 3,851,506 (357)

Antigen presenting capacity of murine splenic myeloid cells [PDF]

, 2017
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are
Hey, Ying-Ying, O'Neill, Helen C, Quah, Benjamin   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The serlogical specificity of the lectin from Lens culinaris [PDF]

, 1973
Lens culinaris, the common lentil, contains a lectin which has been shown to be specific for a glycoprotein saliva antigen and a glycolipoprotein serum antigen.
Heritage, Deborah Ward
core   +1 more source

Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis [PDF]

, 2015
Background: Cronobacter sakazakii and C. malonaticus can cause serious diseases especially in infants where they are associated with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis.
A Lehner, A Muller, A Rahman, AS Shashkov, C Iversen, C Iversen, C Whitfield, DL Daniels, E Hurrell, E Hurrell, E Jackson, E Kucerova, E Kucerova, EE Jackson, F Ramos-Morales, GI Dancer, H Kim, H Sonbol, J Caubilla-Barron, J Caubilla-Barron, J Kajimura, JR Mehall, K Butela, KA Jolley, KA Power, KG Jarvis, KG Jarvis, LL MacLean, LL MacLean, LM Willis, LS Harris, M Blažková, M Czerwicka, M Hobbs, M Scheepe-Leberkühne, MW Gilmour, N Mullane, N Navasa, NP Arbatsky, O Holy, O Holy, P. Ogrodzki, PN Danese, S Hariri, S Joseph, S Joseph, S Joseph, S Joseph, S Joseph, S Kumar, S. Forsythe, SJ Forsythe, SM Townsend, SM Townsend, T Carver, X Zogaj, Y Sun, Y Sun   +57 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Epidemiological investigation of poultry infectious in Kazakhstan (2021–2024)

Frontiers in Veterinary Science
IntroductionThis study examines the epidemiological dynamics and genetic diversity of major avian infectious diseases in Kazakhstan, including highly pathogenic avian influenza (HPAI), Newcastle disease virus (NDV), and others.
Karlygash B. Zikibayeva, Asset A. Svanbayev, Nurlan N. Akhmetsadykov, Kamshat N. Kudaibergenova, Shynar N. Akhmetsadykova, Ernur N. Nurolda, Aidyn I. Kydyrmanov   +6 more
doaj   +1 more source

A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo [PDF]

, 2018
Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Baz Morelli, Adriana, Benson, Robert A., Brewer, James M., Garside, Paul, Hayes, Alan J., Maraskovsky, Eugene, Meehan, Gavin R., Scales, Hannah E., Tomura, Michio, Walters, Anne, Watson, Emma   +10 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Volatile organic compounds of camel milk and shubat across Kazakhstan's regions, seasons, and breeds

Heliyon
Despite extensive research in recent years on camel milk composition and health benefits, limited scientific data exists on the volatile organic compound profiles of camel milk and its fermented product, shubat.
Zauresh Bilal, Askar Kondybayev, Aikerim Ospanova, Helene Tormo, Shynar Akhmetsadykova, Farida Amutova, Bernard Faye, Gaukhar Konuspayeva   +7 more
doaj   +1 more source