Results 91 to 100 of about 2,938,954 (317)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2019 Background: Immunotherapy utilizing T cells genetically modified to express chimeric antigen receptors (CARs) is rapidly emerging as a promising novel treatment for hematological and nonhematological malignancies.
Na Shen (110593) +9 more
core +1 more source
Epidemiological investigation of poultry infectious in Kazakhstan (2021–2024)
Frontiers in Veterinary ScienceIntroductionThis study examines the epidemiological dynamics and genetic diversity of major avian infectious diseases in Kazakhstan, including highly pathogenic avian influenza (HPAI), Newcastle disease virus (NDV), and others.
Karlygash B. Zikibayeva +6 more
doaj +1 more source
Experimental Biology and Medicine, 1957 SummaryHeat stable antibodies to zymosan were produced in rabbits and measured by quantitative agglutination. The increased bactericidal activity for Escherichia coli B resulting from injections of zymosan could be absorbed by E. coli B. Some aspects of the antigenicity of zymosan are discussed.
openaire +2 more sources
Antigens of Bordetella pertussis.III. The Protective Antigen
Experimental Biology and Medicine, 1963 SummaryA method of preparing extracts from Bordetella pertussis with high protective and histamine sensitizing activity is described. From these extracts, starch block electrophoresis yielded active purified fractions which not only protected mice against intracerebral challenge with living B. pertussis cells but also sensitized mice to histamine. From
J, MUNOZ, B M, HESTEKIN
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Long-Range Chromosomal Mapping of the Carcinoembryonic Antigen (CEA) Gene Family Cluster [PDF]
, 1992 A long-range physical map of the carcinoembryonic antigen (CEA) gene family cluster, which is located on the long arm of chromosome 19, has been constructed.
Barnert, Sabine +10 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2007 The clonal selection theory of acquired immunity provides a relatively graceful to comprehend explanation for the diversity and specificity of the acquired immune system.
Jason Brownlee (6868694)
core +1 more source