Results 41 to 50 of about 3,619,273 (388)

Tuning the Antigen Density Requirement for CAR T Cell Activity.

Cancer Discovery, 2020
Insufficient reactivity against cells with low antigen density has emerged as an important cause of CAR resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate that CD19 CAR activity is dependent upon
R. Majzner, Skyler P Rietberg, E. Sotillo, Rui Dong, Vipul T. Vachharajani, Louai Labanieh, J. Myklebust, Meena Kadapakkam, Evan W. Weber, Aidan M Tousley, R. Richards, S. Heitzeneder, S. Nguyen, V. Wiebking, J. Theruvath, Rachel C. Lynn, P. Xu, A. Dunn, R. Vale, C. Mackall   +19 more
semanticscholar   +1 more source

Antigen Stability Controls Antigen Presentation [PDF]

Journal of Biological Chemistry, 2004
We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Jean-Luc Tarride, Michel Desmadril, Denis Servent, André Ménez, Michel Léonetti, Gervaise Moine, Robert Thai   +6 more
openaire   +3 more sources

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

New England Journal of Medicine, 2013
Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute ...
Stephan A Grupp, M. Kalos, D. Barrett, R. Aplenc, David L. Porter, S. Rheingold, D. Teachey, A. Chew, B. Hauck, J. F. Wright, Michael C. Milone, Bruce L. Levine, Carl H June   +12 more
semanticscholar   +1 more source

Preparation and evaluation of Salmonella Enteritidis antigen conjugated with nanogold for screening of poultry flocks [PDF]

Veterinary World, 2017
Aim: The present work aimed to develop lateral flow immunochromatographic strip (ICS) test for detection of Salmonella Enteritidis (SE) specific antibodies in chicken sera.
Hazem Mohammed Ibrahim, Rafik Hamed Sayed, Wafaa Ragab Abdel-Aziz, Rafik Tawfik Soliman   +3 more
doaj   +1 more source

Immunodiagnosis of cattle fascioliasis using a 27 kDa Fasciola gigantica antigen [PDF]

Veterinary World, 2021
Background and Aim: Diagnosis of fascioliasis depends on clinical symptoms and routine laboratory tests. Recently, antibodies and circulating antigens of Fasciola were used for detecting active infections. Therefore, this study aimed to identify Fasciola
Mohamed J. Saadh, Samer A. Tanash, Ammar M. Almaaytah, Issam J. Sa'adeh, Saed M. Aldalaen, Khawla D. Al-Hamaideh   +5 more
doaj   +1 more source

Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Frontiers in Immunology, 2022
Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is
Leena Halim, Kushal K. Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Reuben Benjamin, Richard Dillon, Richard Dillon, David M. Davies, John Maher, John Maher, John Maher, John Maher   +13 more
doaj   +1 more source

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]

, 2016
Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather, Fung, Herman, Goodnow, Christopher, Horikawa, Keisuke, Jeelall, Yogeshraj, Kallies, Axel, Law, Hsei-Di, Nutt, Stephen L, Wang, James   +8 more
core   +1 more source

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

eLife, 2018
Pneumococcal whole cell vaccines (WCVs) could cost-effectively protect against a greater strain diversity than current capsule-based vaccines. Immunoglobulin G (IgG) responses to a WCV were characterised by applying longitudinally-sampled sera, available
Joseph J Campo, Timothy Q Le, Jozelyn V Pablo, Christopher Hung, Andy A Teng, Hervé Tettelin, Andrea Tate, William P Hanage, Mark R Alderson, Xiaowu Liang, Richard Malley, Marc Lipsitch, Nicholas J Croucher   +12 more
doaj   +1 more source

Antigenic Variability [PDF]

Frontiers in Immunology, 2020
Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved epitopes are occluded in vivo and ...
openaire   +3 more sources

Discriminating antigen and non-antigen using proteome dissimilarity: bacterial antigens [PDF]

Bioinformation, 2010
It has been postulated that immunogenicity results from the overall dissimilarity of pathogenic proteins versus the host proteome. We have sought to use this concept to discriminate between antigens and non-antigens of bacterial origin. Sets of 100 known antigenic and nonantigenic peptide sequences from bacteria were compared to human and mouse ...
Kamna Ramakrishnan, Darren R. Flower
openaire   +4 more sources