Results 51 to 60 of about 4,473,616 (249)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1 [PDF]

, 2012
peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn, Judy T Tellam, Rajiv Khanna, David J. Lynn (107188), Lea Lekieffre, Lynn, David J, Khanna, Rajiv, Judy T. Tellam (107182), Zhong, Jie, Jie Zhong (39213), Tellam, Judy T, Jie Zhong, Rajiv Khanna (107190), Lea Lekieffre (107185), Lekieffre, Lea   +14 more
core   +1 more source

Antigen-detection rapid diagnostic tests (Ag-RDTs) and their main characteristics, including the use of universal transport medium (UTM).

, 2022
Antigen-detection rapid diagnostic tests (Ag-RDTs) and their main characteristics, including the use of universal transport medium (UTM).
Ana Rabello (112015), Mariana Lourenço Freire (6996530), Juliana Wilke Saliba (12883745), Daniel Moreira Avelar (10458255), Gláucia Cota (4679719), Carolina Senra de Souza (12883742), Gláucia Queiroz Andrade (12883754), Lindicy Leidicy Alves (12883739), Verônica Faria (12883748), Mariana Junqueira Pedras (5703689), Nara de Oliveira Carvalho (12883751)   +10 more
core   +1 more source

Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus [PDF]

, 1986
Long-term cytolytic T-lymphocyte (CTL) lines that are specific for distinct antigens associated with different phases of the replicative cycle of the murine cytomegalovirus (MCMV) were established by cloning of CTL lines derived from lymph nodes of ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Bühring, Hans-Jörg   +2 more
core   +1 more source

Comparing the Performance of Two Cryptococcal Antigen Detection Tests: Chemiluminescence vs Colloidal Gold Methods. [PDF]

Infect Drug Resist
Xiao-yun Yu,* Lei Zhang,* Yueyue Hu,* Zhongliang Zhu, Yongze Zhu, Xi Li Centre of Laboratory Medicine, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China&ast ...
Yu XY, Zhang L, Hu Y, Zhu Z, Zhu Y, Li X.   +5 more
europepmc   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Diagnosing Blastomycosis: A Review of Laboratory Methods and Clinical Utility

Journal of Fungi
Blastomycosis, caused by dimorphic fungi of the Blastomyces genus, is endemic to regions in North America, including the Great Lakes and other parts of Canada and the United States of America.
Tejaswini Saravanababu, Sameer Elsayed, Ruchika Gupta, Johan Delport, Mohammedreza Rahimi Shahmirzadi, Fatimah AlMutawa   +5 more
doaj   +1 more source

Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection

Synthetic and Systems Biotechnology, 2021
Antigen detection provides particularly valuable information for medical diagnoses; however, the current detection methods are less sensitive and accurate than nucleic acid analysis.
Xiangxiang Zhao, Zhengduo Wang, Bowen Yang, Zilong Li, Yaojun Tong, Yuhai Bi, Zhenghong Li, Xuekui Xia, Xiangyin Chen, Lixin Zhang, Weishan Wang, Gao-Yi Tan   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source