Results 81 to 90 of about 4,473,616 (249)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults [PDF]

, 1996
Western blot analysis using an anti-globin rabbit serum Rb94 revealed a major band of 17 kDa in extracts of Ostertagia ostertagi adults and 4th-stage larvae.
De Marez, Tine, Blaxter, Mark L, Berghen, Paul, Raes, Stefaan, Blaxter, M. L., de Marez, T. M., Berghen, P., de Marez, T.M., Vercruysse, J., de Graaf, Dirk, Raes, S., Vercruysse, Jozef, Moens, L., de Graaf, D.C., Moens, Luc, Blaxter, M.L., de Graaf, D. C.   +16 more
core   +1 more source

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

Journal of Clinical Microbiology
A murine IgG2b monoclonal antibody, named TG11, binding to an extracellular polysaccharide antigen secreted by all Mucorales fungi has been recently developed and integrated into a lateral-flow device (TG11-LFD).
Julie Rousselot, Laurence Millon, Emeline Scherer, Nathalie Bourgeois, Sebastien Imbert, Damien Dupont, Anne Debourgogne, Danièle Maubon, Anne Pauline Bellanger, Christopher R. Thornton   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

High sensitivity of the Bionote Anigen Rapid Rabies Antigen Test in detection of diverse rabies virus variants suggests utility for global rabies control

Journal of Clinical Microbiology
Point-of-care, immunochromatographic tests have not reliably detected the rabies virus and have not utilized a consistent diagnostic protocol. International diagnostic standards established by the World Organization for Animal Health require strategic ...
Lillian A. Orciari, Vaughn Wicker, Sarah Bonaparte, Pamela A. Yager, Claire Hartloge, Kirk Silas, Melanie Seiders, Puja Patel, Annette Regec, Miguel Maldonado-Cedeño, Ramon F. Flores Ramos, Sharon Messenger, Ruth Lopez, Christopher Preas, Alice Price, Kimberlee B. Beckmen, Kristin E. Campbell, Melanie Goff, Chris Vogt, Lisa Wingerter, Kristie L. Schwarzkopf, Yimer Mulugeta, Dessalegn S. Fujaga, Teresa Fields, George Dautu, Pierre Dilius, Crystal Gigante, Rene E. Condori, Christina L. Hutson, Panayampalli S. Satheshkumar, Ryan M. Wallace   +30 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Development of a bead-based Luminex assay using lipopolysaccharide specific monoclonal antibodies to detect biological threats from Brucella species [PDF]

, 2015
Brucella, a Gram-negative bacterium, is classified as a potential bioterrorism agent mainly due to the low dose needed to cause infection and the ability to transmit the bacteria via aerosols.
Angelika Silbereisen, Marco Tamborrini, Gerd Pluschke, Wittwer, Matthias, Silbereisen, Angelika, Schürch, Nadia, Nadia Schürch, Tamborrini, Marco, Matthias Wittwer, Pluschke, Gerd   +9 more
core   +1 more source

Comparison of the analytical and clinical sensitivities of 34 rapid antigen tests with prevalent SARS-CoV-2 variants of concern during the COVID-19 pandemic in the UK

Microbiology Spectrum
Antigen-detection rapid diagnostic tests (Ag-RDTs) have become a central pillar for the management of coronavirus disease worldwide due to their speed and ease of use and are now being developed for use in other emerging outbreaks.
Rachel L. Byrne, Rachel S. Owen, Ghaith Aljayyoussi, Caitlin Greenland-Bews, Konstantina Kontogianni, Anushri Somasundaran, Dominic Wooding, Christopher T. Williams, Margaretha de Vos, Richard Body, Emily R. Adams, Camille Escadafal, Thomas Edwards, Ana I. Cubas-Atienzar   +13 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Clinical Signs and Laboratory Markers Compete Favorably with Antigen Detection of Canine Parvovirus-2 in Dogs

Media Kedokteran Hewan
Thirty dogs (< 1 year) which reported to the Veterinary Teaching Hospital, State Veterinary Hospital and City Veterinary clinic, Ibadan between October 2023 and February 2024 and had clinical signs of depression, vomiting, diarrhea, anorexia, and fever ...
Olatunde Babatunde Akanbi, Olusegun Fagbohun, Aderonke Rachael Kolawole, Olanrewaju Samuel Olaifa, Victor Aliyu, Pius Stephen Ekong, Oluwafemi Babatunde Daodu, James Olukayode Olopade, Victor Olusegun Taiwo   +8 more
doaj   +1 more source