Results 91 to 100 of about 3,953,720 (287)

DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice

Nature Communications
Inducing antigen-specific regulatory T (Treg) cells is a promising strategy for treating autoimmune diseases (AID). Here, we present dendritic cells-CD4⁺ T cells (DC-CD4) bispecific tolerogenic nanovesicles (NV) co-loaded with an antigenic peptide and ...
Lei Zhao, Zhongqiang Gao, Ze Yuan, Xiaodie Yang, Duxin Li, Qian Ren, Yunli Yu, Jie Pan, Yiran Zheng, Xinyun Zhang   +9 more
doaj   +1 more source

IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS

Медицинская иммунология, 2014
. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA).
I. V. Shirinsky, V. S. Shirinsky, C. A. Dinarello   +2 more
doaj   +1 more source

Role of interleukin 18 in rheumatoid arthritis [PDF]

, 2003
No abstract ...
Liew, Foo Y., Wei, Xiao-Qing, Liew, F.Y., Wei, X.Q., McInnes, I. B.   +4 more
core   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis

Acta Pharmaceutica Sinica B
Dendritic cells (DCs) serve as the primary antigen-presenting cells in autoimmune diseases, like rheumatoid arthritis (RA), and exhibit distinct signaling profiles due to antigenic diversity.
Wenxiang Hong, Hongbo Ma, Zhaoxu Yang, Jiaying Wang, Bowen Peng, Longling Wang, Yiwen Du, Lijun Yang, Lijiang Zhang, Zhibin Li, Han Huang, Difeng Zhu, Bo Yang, Qiaojun He, Jiajia Wang, Qinjie Weng   +15 more
doaj   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responses.

PLoS ONE, 2014
ObjectiveIL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of arthritis.
Shivali Justa, Xiaoqun Zhou, Sujata Sarkar   +2 more
doaj   +1 more source

Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing HSP70 peptide

Frontiers in Immunology, 2016
Antigen-specific regulatory T cells (Tregs) directed at self-antigens are difficult to study since suitable specific tools to isolate and characterize these cells are lacking. A T cell receptor (TCR)-transgenic mouse would generate possibilities to study
Manon AA Jansen, Martijn JC Van Herwijnen, Peter JS van Kooten, Aad eHoek, Ruurd eVan Der Zee, Willem eVan Eden, Femke eBroere   +6 more
doaj   +1 more source

Panax notoginseng saponins alleviate osteoporosis and joint destruction in rabbits with antigen-induced arthritis. [PDF]

Exp Ther Med, 2021
Wei CC, Yue LF, You FT, Tao C.
europepmc   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source