Results 211 to 220 of about 3,953,720 (287)

C-type lectin receptors: bone remodeling and therapeutic potential. [PDF]

Bone Res
Kleim M, Bozec A, Weber M, Groetsch B.
europepmc   +1 more source

High‐Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari, Aiman Ali, Clement Hartadi, Annie Shrestha   +3 more
wiley   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications

Immunology, EarlyView.
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang, Fengyu Liu, Yongle Wei, Guoqiang Li, Liujie Zheng, Lin Jin, Feng Luan, Yingze Zhang, Ling Wang, Zhiyong Hou   +9 more
wiley   +1 more source

A Case Series of Raynaud's Phenomenon in the Setting of Immune Checkpoint Inhibitors. [PDF]

J Immunother Precis Oncol
Li YJ, Buni M, Tayar JH, Lu H, Davies M, Gay CM, Elamin Y, Huey R, Jonasch E, Assassi S.   +9 more
europepmc   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Gut Microbial Functional Ecology and Microbiota-Derived Metabolites in Rheumatoid Arthritis Autoimmunity. [PDF]

Cells
Rong X, Zhang X, Tan Y, Lu C.
europepmc   +1 more source

The Interactions Between Acetylcholine and T‐Cells and Their Role in the Immune System: A Scoping Review

Immunology, EarlyView.
Activated T‐cells instigate signalling events leading to the activation of transcription factors, which in turn, act on the nucleus to produce cytokines. We postulate that c‐fos is one of these transcription factors which upregulates the choline acetyltransferase gene responsible for synthesising acetylcholine (ACh).
Jarita Lay, Nicholas Manolios
wiley   +1 more source