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Murine Antigen-Induced Arthritis
, 2007 Antigen induced arthritis is a unilateral T-cell driven model caused by direct injection of an antigen into the knee joint of a FCA preimmunized animal. The chronicity is determined by antigen retention in avascular structures of the joint through charge mediated binding or antibody mediated trapping.
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Antigen-Induced Arthritis: Inflammation and Antigen Handling
Scandinavian Journal of Rheumatology, 1981Data are summarized indicating that the degree and duration of antigen induced arthritis (AIA) influences handling of intra-articular (i.a.) antigen. Long term antigen retention was less in chronic as compared with transient joint inflammation, whereas i.a. antigen was cleared more rapidly from the joint in severe than in moderate AIA. In addition, the
H J, van Beusekom +3 more
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Studies on Antigen-Induced Arthritis in Mice
The Journal of Immunology, 1977Abstract Antigen-induced arthritis was developed in mice as a model of human rheumatoid arthritis by using methylated bovine serum albumin (mBSA) as antigen. It was found that most strains were susceptible, whereas CBA mice were resistant. We therefore investigated the humoral and cell-mediated immune responses to mBSA in resistant mice (
Dieter Brackertz +4 more
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Antigen‐induced arthritis in mice
Arthritis & Rheumatism, 1977AbstractAntigen‐induced arthritis was established in the mouse by immunization with methylated bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertussis vaccine. The knee joint was injected after 21 days with mBSA in saline. The arthritis was chronic, antigen‐specific, and T‐cell dependent in hypothymic nu/nu mice.
Dieter Brackertz +2 more
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