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Antigen processing and presentation
Immunology Letters, 1990An overview of the various aspects of antigen degradation and presentation is given with special emphasis on the possible occurrence of variation in the enzymatic machinery present in different cells or individuals. Different procedures for epitope mapping are also presented as well as the characterization of universal epitopes in humans.
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Proteasomes and Antigen Processing
1997Publisher Summary This chapter discusses the recent findings related to the roles of proteasomes in the major histocompatibility complex (MHC) class I-restricted antigen-processing pathway. One of the most important responses in this antigen-specific immune system is to distinguish correctly non-self-antigens from self-antigens for selective ...
K, Tanaka +4 more
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Mechanisms of Antigen Processing
Immunological Reviews, 1988Using MAb and monovalent Fab probes and saponin permeabilization we have demonstrated that PEC and TA3 B lymphoma-hybridoma cells contain a significant intracellular pool of Ia. At least in TA3 cells, this intracellular pool was independent of protein synthesis. In PEC, adherence caused redistribution of Ia with disappearance of the intracellular pool.
C V, Harding +2 more
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Endosomal proteases and antigen processing
Trends in Biochemical Sciences, 1997T cells are activated by fragments of antigenic proteins bound to major histocompatibility complex (MHC) molecules and displayed on the cell surface. MHC class II proteins scavenge processed protein antigens from within endosomal compartments. The antigenic peptides are generated within these and other intracellular compartments using the array of ...
B, Fineschi, J, Miller
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Antigen Processing Differences Among APC
Human Immunology, 1997The hierarchy of display of determinants on a protein antigen is of critical importance with respect to which T cells will be selected during thymic development, as well as in the induction of mature responses. Activation of T cells will be dependent on unfolding, reduction and chain cleavage of the antigen, and the vagaries of competition with other ...
S C, Schneider, E E, Sercarz
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Pathways of antigen processing
Current Opinion in Immunology, 1991Separate pathways exist for the processing of antigens to be presented by MHC class I and class II molecules. We are beginning to determine the subcellular location of certain events in both pathways.
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Viral effects on antigen processing
Current Opinion in Immunology, 1999Viruses have evolved numerous mechanisms that modulate MHC-mediated antigen presentation, which in turn protect infected cells from T-lymphocyte-mediated immunosurveillance. Recent studies of previously identified viral immunomodulatory proteins reveal the allelic specificity of these proteins, their ability to function in xenogeneic systems and the ...
D M, Miller, D D, Sedmak
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Antigen processing: an interim report
Trends in Biochemical Sciences, 1988Abstract The activation of B cells to synthesize and secrete antibody requires, in the vast majority of cases, the coincident activation of antigen-specific helper T cells to release B-cell growth and differentiation factors. Unlike antibody, which constitutes the B-cell receptor, the T-cell receptor does not bind globular protein antigens in their ...
S K, Pierce, E, Margoliash
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