Results 101 to 110 of about 306,691 (236)

Antigenic and genetic evolution of equine influenza a (H3N8) virus from 1968 to 2007

, 2011
Equine influenza virus is a major respiratory pathogen in horses, and outbreaks of disease often lead to substantial disruption to and economic losses for equestrian industries. The hemagglutinin (HA) protein is of key importance in the control of equine
Chambers, T.M., R. A. M. Fouchier, Lewis, N.S., Bryant, N.A., D. J. Smith, Skepner, E. (Eugene), Fouchier, R.A.M., Fouchier, R.A.M. (Ron), Smith, Derek, N. A. Bryant, D. F. Burke, T. M. Chambers, Mumford, J.A., Burke, DF, Smith, D.J., Elton, D.M., Lewis, NS, D. L. Horton, Fouchier, Ron; id_orcid, Mumford, JA, A. S. Rash, Daly, JM, Russell, C.A., Daly, J.M., J. L. N. Wood, Smith, D.J. (Derek James), E. Skepner, Horton, DL, Russell, CA, Skepner, E, N. S. Lewis, Fouchier, RAM, Lewis, N.S. (Nicola), Burke, D.F., Horton, D.L., J. A. Mumford, Bryant, NA, Rash, AS, J. M. Daly, Smith, DJ, Skepner, E., Russell, C.A. (Colin), Wood, J.L.N., C. A. Russell, D. M. Elton, Wood, JLN, Rash, A.S., Elton, DM, Chambers, TM   +48 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Characterizing Viral Antigenic Drift And Using Immunoglobulin G3 To Increase Antibody Breadth

, 2022
Antigenic drift, the sequential accumulation of substitutions that enable escape from population immunity, is a constant problem for RNA viruses that circulate in the human population.
Bolton, Marcus
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The antigenic architecture of the hemagglutinin of influenza H5N1 viruses

, 2013
Human infection with the highly pathogenic avian influenza A virus H5N1 is associated with a high mortality and morbidity. H5N1 continues to transmit from poultry to the human population, raising serious concerns about its pandemic potential.
Ong, Chi, Nation, Roger L., Rockman, Steve, Huang, Johnny X., Baker, Mark A., Cooper, Matthew A., Li, Jian, Velkov, Tony, Kim, Hyunsuh   +8 more
core   +1 more source

A sequence-based machine learning model for predicting antigenic distance for H3N2 influenza virus

Frontiers in Microbiology
IntroductionSeasonal influenza A H3N2 viruses are constantly changing, reducing the effectiveness of existing vaccines. As a result, the World Health Organization (WHO) needs to frequently update the vaccine strains to match the antigenicity of emerged ...
Xingyi Li, Xingyi Li, Yanyan Li, Yanyan Li, Xuequn Shang, Xuequn Shang, Huihui Kong   +6 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Simulations of Antigenic Variability in Influenza A [PDF]

, 2008
Computational models of the immune system (IS) and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials.
Nuno Fachada, Vitor V. Lopes, Agostinho Rosa, Agostinho C. Rosa   +3 more
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source