Results 171 to 180 of about 306,691 (236)

Evolution and Antigenic Drift of Influenza A (H7N9) Viruses, China, 2017-2019. [PDF]

Emerg Infect Dis, 2020
Zhang J, Ye H, Li H, Ma K, Qiu W, Chen Y, Qiu Z, Li B, Jia W, Liang Z, Liao M, Qi W.   +11 more
europepmc   +1 more source

Deep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic drift. [PDF]

MAbs, 2022
Laroche A, Orsini Delgado ML, Chalopin B, Cuniasse P, Dubois S, Sierocki R, Gallais F, Debroas S, Bellanger L, Simon S, Maillère B, Nozach H.   +11 more
europepmc   +1 more source

Engineering Antigen Density on M13 Bacteriophage for Personalized Nanovaccine

Advanced Healthcare Materials, EarlyView.
Increasing antigen density on the phage capsid impacts phage uptake and antigen cross‐presentation by antigen‐presenting cells, leading to enhanced activation of antitumor CD8+ T cells in the draining lymph nodes. These activated CD8+ T cells subsequently recognize the antigen‐expressing tumors and mediate their specific cytotoxic killing, thereby ...
Shengnan Huang, Allison Madow, Jack Rudrum, Huaiyao Peng, Hao Nghi Luu, Peiyan Dong, Jifa Qi, Angela M. Belcher   +7 more
wiley   +1 more source

Influenza neuraminidase active site proximity assay for rapid profiling of inhibitory antibodies and antigenic drift. [PDF]

NPJ Vaccines
Gao J, Landgraf G, Yuan Y, Yu H, Saeidi S, Kang H, Rakic Martinez M, Giurgea L, Lugovtsev V, Gorman J, Memoli M, Chen X, Ye Z, Daniels R.   +13 more
europepmc   +1 more source

Toward the Next-Generation COVID-19 Vaccines That Circumvent Antigenic Drift while Defusing Viral Infection. [PDF]

ACS Pharmacol Transl Sci, 2021
Fernández A.
europepmc   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

Advanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang, Shunmuga Nathan Shunmuga Nainar, Bing‐Han Zhuang, Shun‐Mao Yang, Hong‐Cheu Lin, Yang‐Hsiang Chan   +5 more
wiley   +1 more source

Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8⁺ T cell receptor repertoire to antigenic drift. [PDF]

Nat Commun
Malone MJ, Huang C, Zhang Y, Qi Y, Williams L, Su LF, Lou J, Jiang N.   +7 more
europepmc   +1 more source

Molecular Analysis of Full-Length VP2 of Canine Parvovirus Reveals Antigenic Drift in CPV-2b and CPV-2c Variants in Central Chile. [PDF]

Animals (Basel), 2021
Alexis VA, Sonia V, Daniela S, Miguel G, Timothy H, Valentina F, Lisette L, Leonardo S.   +7 more
europepmc   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

H128N Substitution in the Sa Antigenic Site of HA1 Causes Antigenic Drift Between Eurasian Avian-like H1N1 and 2009 Pandemic H1N1 Influenza Viruses. [PDF]

Viruses
Meng F, Cheng Z, Feng Z, Zhang Y, Zhang Y, Wang Y, Zhai Y, Kuang P, Qu R, Chen Y, Qiao C, Chen H, Yang H.   +12 more
europepmc   +1 more source