Results 121 to 130 of about 534 (175)

IL‐22Rα1 restrains pancreatic injury independently of its C‐terminal STAT3‐amplifying domain

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
IL‐22R, and to a lesser extent IL‐22, are key drivers of protection in acute pancreatitis. Although the C‐terminal domain of IL‐22R enhances STAT3 activation in the pancreas, it is not required for disease protection. Classical IL‐22R signaling alone is sufficient to control inflammation and promote pancreatic recovery.
Léna Puigdevall, Clara Stewardson, Lysa Dhulst, Emilie Hendrickx, Laure Dumoutier   +4 more
wiley   +1 more source

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T-cell responses during chronic viral infection. [PDF]

J Virol
Hashimoto M, Khan MA, Akhtar A, Agrewala JN, Freeman GJ, Girgis N, Zhang Y, Low S, Quayle SN, Suri A, Ahmed R.   +10 more
europepmc   +1 more source

Mechanistic Insights Into the Association Between Gut Microbiota Diversity and Atherosclerosis, Acute Coronary Syndrome, and Peripheral Arterial Disease Progression

Clinical Cardiology, Volume 49, Issue 9, September 2026.
Proposed gut‐vascular framework linking microbial ecology to atherosclerotic disease. Diet and related exposures shape dysbiosis or microbial resilience; resulting changes in SCFAs, TMAO, bile acids, and LPS may modulate endothelial function, immune activation, and platelet activity, contributing to atherosclerosis, ACS, and PAD.
Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Usamah Sayed, Zarina Nasirova, Quvonch Tursunov, Omer Qutaiba B. Allela, Lara Asim Kzar, Rajashree Panigrahi, Neeraj Bainsal   +7 more
wiley   +1 more source

A ubiquitinated E2-based mRNA vaccine confers complete protection against lethal challenge with classical swine fever virus. [PDF]

J Virol
Zhai H, Gao Y, Wan N, Qu Y, Li S, Li L-F, Zhao T, Hou Q, Sun Y, Wu H, Li Y, Qiu H-J.   +11 more
europepmc   +1 more source

Parallel processing of T cells and natural killer cells to enhance in vivo CAR T cell activity against blood and solid cancers

Clinical &Translational Immunology, Volume 15, Issue 9, 2026.
Abstract Objectives Despite their anti‐cancer properties, natural killer (NK) cells are discarded during CAR T cell manufacturing. NK cells display promising responses as a cell therapy, exhibiting remarkable safety at high doses. Moreover, NK cells have complementary cytokine profiles and distinct antigen‐recognition pathways to supplement CAR T cell ...
Lachlan J Dobson, Patrick W Marron, Ariana HT Drabble, Thiloma D Liyanage, Kristine C Pe, Clare Y Slaney, Barry D Hock, Alexander D McLellan   +7 more
wiley   +1 more source

Development and evaluation of multiepitope fusion proteins for serological diagnosis of animal brucellosis. [PDF]

Microbiol Spectr
Guo L, Pei Q, Zhao S, Qi X, Chen Y, Yang P, Du Y, Sun M, Yin D, Zhan T.   +9 more
europepmc   +1 more source

Multiomics analyses revealed the roles of the epithelial–mesenchymal transition and novel early candidate diagnostic biomarkers in neonatal necrotising enterocolitis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
In infants with necrotising enterocolitis (NEC), excessive inflammation and epithelial cell death promote the epithelial–mesenchymal transition (EMT), leading to damage to intestinal barriers and the translocation of bacteria and toxins. In addition, inflamed epithelia release cytokines to strengthen the inflammatory response.
Xiao‐Chen Liu, Guo‐Bin Liu, Chen Cheng, Jin Zhu, Fei‐Fan Chen, Ying Ji, Yu‐Ni Zhang, Xiao‐Lin Yan, Qing Wang, Xin‐Yu Li, Qing Ai, Yuan Shi, Yu He   +12 more
wiley   +1 more source

Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course. [PDF]

PLoS Biol
Hay JA, Zhu H, Jiang CQ, Kwok KO, Shen R, Kucharski A, Yang B, Read JM, Lessler J, Cummings DAT, Riley S.   +10 more
europepmc   +2 more sources

A colloidal gold immunochromatographic test strip based on McAbs anti-S protein to detect porcine epidemic diarrhea virus. [PDF]

Microbiol Spectr
Liu C, Wang W, Wang F, Hou J, Shi Q, Song Q, Yuan C.   +6 more
europepmc   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source