Results 111 to 120 of about 534 (175)

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Direct airway delivery of a humanized anti-H7N9 neutralizing antibody broadly protects against divergent H7 influenza viruses in the mouse model. [PDF]

J Virol
Yu W, He X, Zhao J, Dou Y, Hu T, Chen X, Ma X, Wang X, Hu S, Hu J, Liu X, Hu Z.   +11 more
europepmc   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Enhanced Influenza Vaccines Extend A(H3N2) Antibody Reactivity in Older Adults but Prior Vaccination Effects Persist. [PDF]

Clin Infect Dis
Fox A, Sánchez-Ovando S, Carolan L, Hadiprodjo AJ, Chen Y, Ho F, Cheng SMS, Thompson MG, Iuliano AD, Levine MZ, Valkenburg SA, Ip DKM, Peiris JSM, Sullivan SG, Cowling BJ, Leung NHL.   +15 more
europepmc   +1 more source

Increased Amyloidogenic Neuronal Injury in HIV‐1–infected APP‐KI Alzheimer's disease mice

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION A higher incidence of dementia, including Alzheimer's‐like pathology, is observed in aged people living with human immunodeficiency virus‐1 (HIV‐1). However, mechanisms linking HIV‐1 to Alzheimer's disease (AD) pathology remain unclear, due to the lack of animal models that allow for concurrent studies of HIV‐1 and AD.
Shaurav Bhattarai, Emma G. Foster, Rana Kadry, Yaman Lu, Mohit Kumar, Syed Qasim, Amrita Mitra, Harsh Pathak, Larisa Y. Poluektova, Santhi Gorantla, R. Lee Mosley, Pravin Yeapuri, Howard E. Gendelman   +12 more
wiley   +1 more source

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield? [PDF]

J Exp Med
Matz HC, Ellebedy AH.
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

The Potential for Twice-Annual Influenza Vaccination to Reduce Disease Burden. [PDF]

Influenza Other Respir Viruses
Zhong S, Thompson MG, Cowling BJ.
europepmc   +1 more source

The High‐Sensitivity C‐Reactive Protein−Albumin−Lymphocyte Index Is a Prognostic Marker for All‐Cause and Cardiovascular Mortality in Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, Volume 108, Issue 3, Page 1034-1046, September 1, 2026.
ABSTRACT Background Inflammation and immune dysfunction may worsen the prognosis of patients with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess whether the high‐sensitivity C‐reactive protein–albumin–lymphocyte index (hsCALLYI) could be used to predict the prognosis of STEMI patients who received emergency ...
Xinuo Ma, Wei Zhang, Ningli Zhang, Qinghua Zhong, Tao Shi, Sirui Yang, Fazhi Yang, Yujuan Peng, Lixing Chen   +8 more
wiley   +1 more source

Antigenic drift expands influenza viral escape pathways from recalled humoral immunity. [PDF]

Immunity
Maurer DP, Vu M, Schmidt AG.
europepmc   +1 more source