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Antigenic variation in Trypanosoma equiperdum
Research in Microbiology, 1991Trypanosoma equiperdum is an African trypanosome that causes dourine in horses. Like the other African trypanosomes, T. equiperdum escapes elimination by the immune system of its host by using an elaborate system of antigenic variant. The trypanosomes are covered by a coat consisting of a single protein called the variable surface glycoprotein (VSG ...
C, Roth +5 more
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Antigenic variation of trypanosomes
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1985Etude de la biologie des trypanosomes et de la variation antigenique. Synthese des VSGS et structure de la paroi externe. Structure des telomeres, organisation chromosomique, specificite des genes telomeriques, activation non duplicative, conversion des telomeres transcription chez les trypanosomatides, controle des sites d'expression ...
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Antigenic variation in trypanosomes
Nature, 1978In its mammalian host, Trypanosoma brucei is able to change the antigenic character of its glycoprotein surface coat and so evade the host's immune response. This phenotypic change seems to occur spontaneously in 1 in 10,000 individuals but is not due to genetic mutation: host antibody is not necessary for its induction but plays a selective part in ...
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Phase variation and antigenic variation
2005A review on the best understood mechanisms of phenotypic diversification by phase variation and antigenic variation, and their functions. Topics discussed include DNA inversion, gene conversion, phase variation by slipped-strand mispairing, phase variation by an epigenetic mechanism, influence of environmental conditions on phase variation, and phase ...
Villemur, Richard, Déziel, Éric
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Antigenic variation in visna virus
Cell, 1979Two antigenic variants of visna virus were isolated sequentially from a single sheep inoculated with a plaque-purified strain of virus designated 1514. The genetically stable variants, LV1-1 and LV1-4, are of two classes: LV1-1 is partially neutralized by antibody to the inoculum strain 1514, while LV1-4 is not neutralized by antibody to 1514.
J V, Scott +4 more
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ANTIGENIC VARIATION IN AFRICAN TRYPANOSOMES
Annual Review of Microbiology, 1985Revue bibliographique des etudes sur la base moleculaire de la variation antigenique chez les trypanosomes, avec presentation d'un modele a 2 etapes pour l'activation d'un gene de VSG (glycoproteine de surface specifique de variant)
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Antigenic Variation in Giardia lamblia
Experimental Parasitology, 1989Giardia lamblia undergo surface antigenic variation in vitro and in vivo. The presence of variant trophozoites can be detected in clones after exposure to cytotoxic monoclonal antibodies. Surviving Giardia (progeny) no longer possess the initial major surface antigen which is replaced by new antigens.
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2000
Abstract In this chapter, we discuss more complicated models of antigenic variation. In the simple models of Chapter 12, all viral strains had the same kinetic parameters. Now we assume that strains may differ in all their characteristic parameters, such as replication rate, immunological properties and cytopathicity.
Martin A Nowak, Robert M May
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Abstract In this chapter, we discuss more complicated models of antigenic variation. In the simple models of Chapter 12, all viral strains had the same kinetic parameters. Now we assume that strains may differ in all their characteristic parameters, such as replication rate, immunological properties and cytopathicity.
Martin A Nowak, Robert M May
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2000
Abstract Soon after the discovery of HIV, in the mid-1980s, it was realized that the virus was characterized by extensive genetic variability. Beatrice Hahn and George Shaw, at first working with Robert Gallo at the NIH and later at the University of Alabama at Birmingham, were among the first to show that isolates of HIV differ ...
Martin A Nowak, Robert M May
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Abstract Soon after the discovery of HIV, in the mid-1980s, it was realized that the virus was characterized by extensive genetic variability. Beatrice Hahn and George Shaw, at first working with Robert Gallo at the NIH and later at the University of Alabama at Birmingham, were among the first to show that isolates of HIV differ ...
Martin A Nowak, Robert M May
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Antigenic Variation in Babesia
1977As babesiosis has been the subject of several recent reviews (Mahoney 1972; Riek 1968; Ristic 1970) and is the subject of another chapter in this volume (Callow, Chapter 8), I will only briefly present the evidence now available to show that antigenic variation also occurs in this disease.
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