Results 111 to 120 of about 62,650 (255)
Frontiers in ImmunologyBackgroundCartilage repair is a significant clinical challenge because of the limited intrinsic healing capacity. Current therapeutic strategies, such as cell transplantation therapy, aim to overcome this challenge by replacing damaged tissue with ...
Kentaro Homan +13 more
doaj +1 more source
Effects of tannic acid on antigenicity and membrane contrast in ultrastructural immunocytochemistry.
, 1992 We have modified our previous method for immunogold staining of unosmicated, plastic-embedded tissue by addition of tannic acid as a post-fixative to increase membrane contrast.
A L Hubbard +3 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
, 2015 The vertical axis represents antigenicity values. Closed black arrows indicate the residues with antigenicity values different from that of the D39 strain (allele 1) reference sequence.
Ki Wook Yun (781368) +3 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Loss of meal antigenicity during digestion in Sepia officinalis (Cephalopoda: Sepioidea)
, 1992 Some of the limits to the use of serology to identify prey species in the digestive tracts of cephalopods have been evaluated. Cuttlefish, Sepia officinalis, were given meals of krill slurry (Euphausia superba).
Boyle, PR +3 more
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Computer-predicted antigenicity score is much higher for TSSA-II/V/VI sequence than TSSA-I.
, 2014 Polymorphic sequences of [A] TSSA-I and [B] TSSA-II/V/VI showing regions of high antigenicity in red, and low antigenicity in blue. A few amino acid replacements in TSSA-I lead to disappearance of the immunogenic epitope that is present in TSSA-II/V/VI ...
Patricio Diosque (216764) +14 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source