Results 221 to 230 of about 1,199,934 (306)

Characterization of Full‐Length Antibody Complexes Through HDX‐Mass Spectrometry Coupled With NMR Spectroscopy: New Insight Into Avelumab/PD‐L1 Interaction

Angewandte Chemie, EarlyView.
Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco, Fabio Baroni, Angela Capolupo, Sofia Petrocchi, Jonathan Zöller, Linda Cerofolini, Pasquale Russomanno, Rebecca Calamandrei, Bianca Susini, Siyu Lin, Fabio D'Amici, Enrico Ravera, Julian Langer, Marco Fragai   +13 more
wiley   +2 more sources

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease. [PDF]

iScience
Griesbaum MG, Vogl T, Visschedijk MC, Festen EAM, Dijkstra G, Weinberger A, Segal E, Weersma RK, Bourgonje AR.   +8 more
europepmc   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Coupling Exponential Rolling Circle Amplification to Lateral Flow Devices for Point‐of‐Care Detection of Viral RNA

Angewandte Chemie, EarlyView.
A new exponential RCA (E‐RCA) system was developed and coupled to a toehold system for release of a bridging DNA, allowing for lateral flow detection. The E‐RCA method uses a secondary primer (P2) that binds RCA products (RCAP) to generate extended P2 products that can re‐prime a partially self‐complementary circular template, generating a complete ...
Amal Mathai, Monsur Ali, Yingfu Li, John D. Brennan   +3 more
wiley   +2 more sources

Identification and Evaluation of Conserved Subunit Vaccine Candidates Conferring Cross-Serotype Protection Against <i>Streptococcus suis</i> Serotypes 2, 7, 8, and 9. [PDF]

Transbound Emerg Dis
Kang S, Zhuang H, Peng Z, Chen L, Zhu J, Wu Z.   +5 more
europepmc   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Chemical Synthesis and Immunological Evaluation of Escherichia coli O29, Shigella dysenteriae Serotype 11, and Proteus vulgaris O12 O-Antigen Oligosaccharides. [PDF]

Angew Chem Int Ed Engl
Li X, Wang X, Deng L, Ji X, Tu Y, Liu C, Wang Z, Wang L, Ye X, Yang Y, Zhang Q.   +10 more
europepmc   +1 more source

Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females. [PDF]

Elife
Vantomme H, Quiniou V, Adda L, Jouannet C, Mhanna V, Albalaa C, Barennes P, Coatnoan N, Diderot V, Dubois J, Fourcade G, Le Gouge K, Nguekap Tchoumba OF, Pezous M, Stys P, Six A, Mariotti-Ferrandiz E, Klatzmann D.   +17 more
europepmc   +1 more source

Smart nanoparticle vaccines integrate nanotechnology artificial intelligence and immunoengineering for precision immunization. [PDF]

Discov Nano
Morshedi I, Roodaki Z, Gheibi P, Zamani G, Jaberi A, Hasan J, Chaloob S, Teymourzadeh M, KarkonShayan S.   +8 more
europepmc   +1 more source

WH01-3A: a DIVA-compliant, ApxIA, ApxIIA, and ApxIIIA expressing Actinobacillus pleuropneumoniae live attenuated vaccine strain that protects mice and pigs against homologous and heterologous serovars. [PDF]

Vet Res
Peng L, Zhang Q, Zhou Q, Han W, Yang D, Luo Z, Liu Z, Zhou R, Song Y, Langford PR, Li L.   +10 more
europepmc   +1 more source