Results 211 to 220 of about 830,599 (290)

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

First evidence of clinical protection from an EEHV1A mRNA vaccine in naturally infected juvenile elephants. [PDF]

J Virol
Wenninger M, Farris L, Heinz J, Peng R, Hayward GS, Watts J, Pollet J, Nollman J, Ling PD.   +8 more
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Magnesium Status in Celiac Disease: Potential Links with Neuroinflammatory Pathways and Gut-Brain Axis Dysfunction. [PDF]

Int J Mol Sci
Popa E, Popa AE, Poroch M, Poroch V, Hatneanu AM, Slanina AM, Ungureanu MI, Dramba T, Petroaie AD, Bacusca AI, Bacoanu G, Coman EA.   +11 more
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

<i>In silico</i> discovery and serological validation of <i>Trypanosoma cruzi</i>-specific B-cell epitopes for high-precision Chagas disease diagnosis. [PDF]

Front Microbiol
Candia-Puma MA, Goyzueta-Mamani LD, Barazorda-Ccahuana HL, Câmara RSB, Pereira IAG, Silva AL, Rodrigues MM, Assis BPN, Chaves AT, Corrêa LAVA, Rocha MODC, Gonçalves DU, Gonçalves AAM, de Moura AB, Galdino AS, Machado-de-Avila RA, Giunchetti RC, Coelho EAF, Chávez-Fumagalli MA.   +18 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Co-Administration of Trans-Resveratrol and L-Carnitine with a High-Fat and High-Carbohydrate Diet Modulates Liver Transcriptome in Obesity-Resistant DBA/2J Mice. [PDF]

Int J Mol Sci
Gmoshinski IV, Trusov NV, Shipelin VA, Nikityuk DB.   +3 more
europepmc   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Improving the immunogenicity of <i>E. coli</i> FimH via multivalent display on I53-50 nanoparticles. [PDF]

Front Immunol
Cole RS, Silmon de Monerri NC, Lypowy J, Ponce C, Kobylarz C, Liu L, Kasbo Z, Kepl E, Ciolino T, Illenberger A, Gallardo L, Laporte A, Baranova D, Ravichandran R, Chorro LO, Donald RGK, Simon R, King NP.   +17 more
europepmc   +1 more source