Results 21 to 30 of about 1,436,444 (347)
Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials. [PDF]
PLoS ONE, 2013 Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a chimeric antigen receptor (CAR) with specificity derived from the scFv region of a CD19 ...
Bipulendu Jena +6 more
doaj +1 more source
Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]
, 2012 T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor +8 more
core +1 more source
Cells, 2022 Given the importance of B lymphocytes in inflammation and immune defense against pathogens, mice transgenic for Cre under the control of Cd19 promoter (Cd19Cre/+ mice) have been widely used to specifically investigate the role of loxP-flanked genes in B ...
Ying Zhao +9 more
doaj +1 more source
Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis
Frontiers in Immunology, 2023 IntroductionControlling pulmonary Mycobacterium avium complex (MAC) disease is difficult because there is no way to know the clinical stage accurately. There have been few attempts to use cell-mediated immunity for diagnosing the stage.
Yoshiro Yamashita +16 more
doaj +1 more source
Immunotherapeutic potential of blinatumomab-secreting γ9δ2 T Cells
Translational Oncology, 2023 Previous studies have explored the use of engineered blinatumomab-secreting autologous αβ T cells for CD19-targeted cancer therapy. To create a more flexible allogeneic delivery system, we utilized γ9δ2 T cells rather than αβ T cells in a similar ...
Shang-Ju Wu +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Cellular immunotherapy represented by CD19-directed chimeric antigen receptor T (CAR-T) cells has achieved great success in recent years. An increasing number of CAR-T therapies are being developed for cancer treatment, but the frequent and varied ...
Yin-Yin Zhang +9 more
semanticscholar +1 more source
Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor [PDF]
Journal of Immunotherapy, 2009 T cells can be engineered to express the genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. We constructed and compared 2 CARs that contained a single chain variable region moiety that recognized CD19. One CAR contained the signaling moiety of the 4-1BB molecule and the other did not.
James N, Kochenderfer +7 more
openaire +2 more sources
Hematology/Oncology and Stem Cell Therapy, 2013 BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo +7 more
doaj +1 more source
BLDE University Journal of Health Sciences, 2022 BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease as it affects multiple lineages of hematopoietic cells. AIMS AND OBJECTIVES: This study aims to (1) evaluate the immunophenotypic findings of AML patients, (2) correlate the ...
Mekhala Rao +3 more
doaj +1 more source
Clinical Microbiology and Infection, 2018 BACKGROUND The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies.
M. Mikulska +6 more
semanticscholar +1 more source