Results 21 to 30 of about 75,785 (301)
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]
, 2016 Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather +8 more
core +1 more source
Immunotherapeutic potential of blinatumomab-secreting γ9δ2 T Cells
Translational Oncology, 2023 Previous studies have explored the use of engineered blinatumomab-secreting autologous αβ T cells for CD19-targeted cancer therapy. To create a more flexible allogeneic delivery system, we utilized γ9δ2 T cells rather than αβ T cells in a similar ...
Shang-Ju Wu +3 more
doaj +1 more source
Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]
, 2012 T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor +5 more
core +1 more source
Natural Expression of the CD19 Antigen Impacts the Long-Term Engraftment but Not Antitumor Activity of CD19-Specific Engineered T Cells [PDF]
The Journal of Immunology, 2010 Abstract T cells gene-modified to express chimeric Ag receptors (CARs) have shown potent antitumor activity in vivo and are in clinical trials at locations worldwide. However, CAR activity has been investigated in mouse models in which Ag expression is restricted to the tumor.
Cheadle, Eleanor J. +5 more
openaire +2 more sources
Protection against pertussis in humans correlates to elevated serum antibodies and memory B cells [PDF]
, 2017 Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Carsetti, Rita +13 more
core +1 more source
Hematology/Oncology and Stem Cell Therapy, 2013 BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo +7 more
doaj +1 more source
BLDE University Journal of Health Sciences, 2022 BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease as it affects multiple lineages of hematopoietic cells. AIMS AND OBJECTIVES: This study aims to (1) evaluate the immunophenotypic findings of AML patients, (2) correlate the ...
Mekhala Rao +3 more
doaj +1 more source
Biomedicines, 2023 Background: Therapeutic options for CD19+ relapses after anti-CD19 CAR-T cells are still debated; second infusion of anti-CD19 CAR-T cells, therapeutic antibodies, or targeted therapies can be discussed.
Audrey Grain +6 more
doaj +1 more source
Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. [PDF]
, 2017 Natural antibodies contribute to tissue homeostasis and protect against infections. They are secreted constitutively without external antigenic stimulation.
Baumgarth, Nicole +5 more
core +1 more source
Folia Histochemica et Cytobiologica, 2010 Numerous experimental data indicate that B-CLL development and progression are influenced by antigenic pressure. It can not be excluded that these antigens may originate from bacteria and viruses.
Barbara Marzec-Kotarska +4 more
doaj +1 more source