Results 61 to 70 of about 233,497 (306)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Association Between Serum Ferritin and CD19/CD34 Expression in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Bioscience and Applied Research
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, characterized by malignant proliferation and accumulation of lymphoblasts in the bone marrow.
Karrar Tikki, Haider Jaffat
doaj   +1 more source

Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data

Pharmaceutics, 2020
Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy that has revolutionized the treatment of certain hematological malignancies, including B-cell non-Hodgkin lymphoma (NHL) and B-cell acute lymphoblastic leukemia
Gils Roex, Tom Feys, Yves Beguin, Tessa Kerre, Xavier Poiré, Philippe Lewalle, Peter Vandenberghe, Dominique Bron, Sébastien Anguille   +8 more
doaj   +1 more source

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]

, 2013
BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...
Kaufmann, S.H.E., Ambrose, Lyn R., Gomez, M., Martin Ota (198869), Lalor, M., Donkor Simon, Novel N Chegou, Kees Franken, Willem Hanekom (23103), Gerhard Walzl (149313), Mihret, A., Crampin, Amelia C, Simon Donkor (343534), Parida, S., Thiel Bonnie A., Hazel M Dockrell, Hanekom, Willem, GCGH Biomarkers for TB consortium, Amelia C Crampin, Parida, Shreemanta K., Kassa, Desta, Loxton, Andre G., Gomez, M.P., Martin Ota, Crampin, Amelia C., Loxton, Andre G, Rawleigh Howe (456745), Hanekom Willem, Parida Shreemanta K., W. Henry Boom (125099), Simon Donkor, Lalor, Maeve K., Ambrose, Lyn R, Andre G. Loxton (160294), Howe Rawleigh, Dockrell Hazel M., Kassa Desta, Gomez, Marie P., Boom, W. Henry, Sutherland, Jayne S, Franken Kees, Ota, Martin, Stefan H E Kaufmann, GCGH Biomarkers TB Consortium, Stefan H. E. Kaufmann (149315), Walzl, G., Crampin, A.C., Mayanja-Kizza Harriet, Sutherland, Jayne S., Michel R. Klein (160302), Lalor Maeve K., Black, Gillian F, Chegou Novel N., Black, G., Harriet Mayanja-Kizza (78637), Donkor, S., Maeve K Lalor, Gomez Marie P., Boom, W.H., Donkor, Simon, Kassa, D., Loxton, A.G., Kees Franken (456747), Amelia C. Crampin (239427), Ambrose, L.R., Desta Kassa (456743), Crampin, A., Black, Gillian F., Thiel, Bonnie A., Ambrose Lyn R., Dockrell, Hazel M., Lyn R Ambrose, Adane Mihret, Hazel M. Dockrell (255469), Klein Michel R., Parida, Shreemanta K, Franken, K., Dockrell, H.M., Walzl Gerhard, Kaufmann, Stefan H.E., Boom, W Henry, Shreemanta K. Parida (149299), Klein, Michel R., Chegou, Novel N, Klein, M.R., Bonnie A Thiel, Lyn R. Ambrose (456742), Ota Martin, Thiel, B.A., Andre G Loxton, Sutherland, J., Shreemanta K Parida, Harriet Mayanja-Kizza, Ottenhoff Tom H. M., Ota, M., Loxton, A., Howe, R., Mayanja-Kizza, H., Ottenhoff, Tom HM, Tom H M Ottenhoff, Cardona, Pere-Joan, Ottenhoff, T.H.M., Willem Hanekom, Crampin Amelia C., Gomez, Marie P, Novel N. Chegou (160288), Chegou, Novel N., Klein, M., Sutherland, J.S., Lalor, M.K., Thiel, Bonnie A, Bonnie A. Thiel (456748), Maeve K. Lalor (356874), Ottenhoff, T., Walzl, Gerhard, Gillian F. Black (149301), Boom W. Henry, Ambrose, L., Hanekom, W., Marie P Gomez, Lalor, Maeve K, Adane Mihret (456744), Chegou, N.N., Marie P. Gomez (456746), Jayne S Sutherland, Sutherland Jayne S., Klein, Michel R, Chegou, N., Jayne S. Sutherland (334202), Kaufmann, Stefan HE, Parida, S.K., Mihret Adane, Kaufmann Stefan H. E., Ottenhoff, Tom H.M., W Henry Boom, Rawleigh Howe, Thiel, B., Gerhard Walzl, Tom H. M. Ottenhoff (160303), Gillian F Black, Dockrell, H., Black Gillian F., Howe, Rawleigh, Boom, W., Black, G.F., Loxton Andre G., Desta Kassa, Ottenhoff, Tom H M, Kaufmann, S., Mihret, Adane, Franken, Kees, Mayanja-Kizza, Harriet, Michel R Klein, Kaufmann, Stefan H E, Dockrell, Hazel M   +154 more
core   +3 more sources

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology
Development of chimeric antigen receptor T‐cell therapy has revolutionized the treatment of B‐cell malignancies, although challenges such as antigen escape and tumor heterogeneity often decrease treatment success. Modular CARs targeting multiple antigens
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
doaj   +1 more source

A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus

Acta Pharmaceutica Sinica B
Tripterygium wilfordii Hook F (TWHF) is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus (SLE), with triptolide (TP) as its main active ingredient.
Lai Wang, Haoyuan Yin, Jiao Jiang, Qilin Li, Changxing Gao, Wenrui Li, Bo Zhang, Yue Xin, Hongyang Li, Ming Zhao, Qianjin Lu   +10 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Chimeric antigen receptor–modified T cells: CD19 and the road beyond [PDF]

Blood, 2018
Abstract The ability to harness a patient’s immune system to target malignant cells is now transforming the treatment of many cancers, including hematologic malignancies. The adoptive transfer of T cells selected for tumor reactivity or engineered with natural or synthetic receptors has emerged as an effective modality, even for patients
Alexander I. Salter, Margot J. Pont, Stanley R. Riddell   +2 more
openaire   +2 more sources

The CD19/CD21 Complex Functions to Prolong B Cell Antigen Receptor Signaling from Lipid Rafts [PDF]

, 2001
The CD19/CD21 complex functions to significantly enhance B cell antigen receptor (BCR) signaling in response to complement-tagged antigens. Recent studies showed that following antigen binding the BCR translocates into plasma membrane lipid rafts that ...
Paul C. Cheng, Cherukuri, Anu, Cheng, Paul C., Susan K. Pierce, Pierce, Susan K., Sohn, Hae Won, Anu Cherukuri, Hae Won Sohn   +7 more
core   +1 more source