Results 21 to 30 of about 39,155 (236)

Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes.

PLoS ONE, 2019
To confirm that neoplastic monocyte-derived collagen- and fibronectin-producing fibrocytes induce bone marrow (BM) fibrosis in primary myelofibrosis (PMF), we injected PMF BM-derived fibrocyte-precursor CD14+/CD34- monocytes into the tail vein of NOD ...
Taghi Manshouri, Srdan Verstovsek, David M Harris, Ivo Veletic, Xiaorui Zhang, Sean M Post, Carlos E Bueso-Ramos, Zeev Estrov   +7 more
doaj   +1 more source

Association Between Serum Ferritin and CD19/CD34 Expression in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Bioscience and Applied Research
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, characterized by malignant proliferation and accumulation of lymphoblasts in the bone marrow.
Karrar Tikki, Haider Jaffat
doaj   +1 more source

Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin

Scientific Reports, 2021
Arsenic exposure poses numerous threats to human health. Our previous work in mice has shown that arsenic causes anemia by inhibiting erythropoiesis. However, the impacts of arsenic exposure on human erythropoiesis remain largely unclear.
Guanghua Wan, Sebastian Medina, Haikun Zhang, Rong Pan, Xixi Zhou, Alicia M. Bolt, Li Luo, Scott W. Burchiel, Ke Jian Liu   +8 more
doaj   +1 more source

Evaluation of Angiogenesis in Colorectal Carcinoma by CD34 Immunohistochemistry Method and its Correlation with Clinicopathologic Parameters [PDF]

Acta Medica Iranica, 2009
The basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor-induced angiogenesis. The aim of this study was to evaluate the angiogenesis in colorectal carcinoma by microvascular density (MVD) determination with IHC ...
Nourieh Sharifi, Kamran Ghaffarzadegan, Hossein Ayatollahi, Mohammad Taghi Shakeri, Mohammad Hadi Sadeghian, Jafar Bordbar Azari   +5 more
doaj   +1 more source

Antigen CD34+ marrow cells engraft lethally irradiated baboons. [PDF]

Journal of Clinical Investigation, 1988
The CD34 antigen is present on 1-4% of human marrow cells including virtually all hematopoietic progenitors detected by in vitro assays. Since the anti-CD34 monoclonal antibody 12-8 reacts with a similar marrow population in baboons, it was possible to test whether this antigen is expressed by stem cells responsible for hematopoietic reconstitution in ...
R J, Berenson, R G, Andrews, W I, Bensinger, D, Kalamasz, G, Knitter, C D, Buckner, I D, Bernstein   +6 more
openaire   +2 more sources

CD34+ stem cells from umbilical cord blood

Clinics and Practice, 2011
We describe the relation between umbilical cord clamping time and two different enrichment system of CD34+ stem cells from umbilical cord blood with the proliferative ability and bone marrow reconstitution of the stem cells obtained.
Carlo Pafumi, Vito Leanza, Antonio Carbonaro, Gianluca Leanza, Alessandra Iemmola, Giusi Abate, Maria Grazia Stracquadanio, Alfio D’Agati   +7 more
doaj   +1 more source

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture. [PDF]

PLoS ONE, 2010
BACKGROUND: Haematopoiesis is sustained by haematopoietic (HSC) and mesenchymal stem cells (MSC). HSC are the precursors for blood cells, whereas marrow, stroma, bone, cartilage, muscle and connective tissues derive from MSC.
Rowayda Peters, Monika J Wolf, Maries van den Broek, Mario Nuvolone, Stefanie Dannenmann, Bruno Stieger, Reto Rapold, Daniel Konrad, Arnold Rubin, Joseph R Bertino, Adriano Aguzzi, Mathias Heikenwalder, Alexander K Knuth   +12 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting novel antigens in the arterial wall in thromboangiitis obliterans.

Folia Histochemica et Cytobiologica, 2010
Thromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis.
Murat Akkus, Pergin Atilla, Ayse Yildirim, Ender Topal, Elif Guzel, Attila Dagdeviren   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source