Results 41 to 50 of about 1,140,023 (299)

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients [PDF]

, 2017
Background: Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously expressed member of the protein tyrosine phosphatase family known to act as a tumor suppressor gene in many different neoplasms with mechanisms of inactivation including ...
Al Sayab, Ali, Al-Dewik, Nader, Fiorini, Zeno, Holyoake, Tessa L., Ismail, Mohamed A., Krampera, Mauro, Lorenzetto, Erika, Mafficini, Andrea, Monne, Maria, Moratti, Elisabetta, Pellicano, Francesca, Sorio, Claudio, Tecchio, Cristina, Tomasello, Luisa, Vezzalini, Marzia, Yassin, Mohamed   +15 more
core   +3 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin

Scientific Reports, 2021
Arsenic exposure poses numerous threats to human health. Our previous work in mice has shown that arsenic causes anemia by inhibiting erythropoiesis. However, the impacts of arsenic exposure on human erythropoiesis remain largely unclear.
Guanghua Wan, Sebastian Medina, Haikun Zhang, Rong Pan, Xixi Zhou, Alicia M. Bolt, Li Luo, Scott W. Burchiel, Ke Jian Liu   +8 more
doaj   +1 more source

Evaluation of human umbilical cord blood as a source of embryonic stem cells [PDF]

, 2013
Human umbilical cord blood (HUCB) has been poorly characterised as a source of embryonic stem cells (ESCs). The aim of this study, therefore, was to evaluate HUCB as source of mesenchymal stem cells (MSCs) with embryonic characteristics.
El-Sheemy, Mohamed, Eremin, Oleg, Hussain, Issam, Magd, Salah A.   +3 more
core   +2 more sources

Using the nonhuman primate model of HCMV to guide vaccine development. [PDF]

, 2014
The natural history of human cytomegalovirus (HCMV) is inextricably associated with mucosal surfaces. The vast preponderance of primary infections occur following mucosal exposure to infectious virions, and the high seroprevalence of HCMV throughout the ...
Barry, Peter A, Deere, Jesse D
core   +3 more sources

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S., Edwards, J., Mukherjee, R., Underwood, M.A.   +3 more
core   +1 more source

CD34+ stem cells from umbilical cord blood

Clinics and Practice, 2011
We describe the relation between umbilical cord clamping time and two different enrichment system of CD34+ stem cells from umbilical cord blood with the proliferative ability and bone marrow reconstitution of the stem cells obtained.
Carlo Pafumi, Vito Leanza, Antonio Carbonaro, Gianluca Leanza, Alessandra Iemmola, Giusi Abate, Maria Grazia Stracquadanio, Alfio D’Agati   +7 more
doaj   +1 more source

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture. [PDF]

PLoS ONE, 2010
BACKGROUND: Haematopoiesis is sustained by haematopoietic (HSC) and mesenchymal stem cells (MSC). HSC are the precursors for blood cells, whereas marrow, stroma, bone, cartilage, muscle and connective tissues derive from MSC.
Rowayda Peters, Monika J Wolf, Maries van den Broek, Mario Nuvolone, Stefanie Dannenmann, Bruno Stieger, Reto Rapold, Daniel Konrad, Arnold Rubin, Joseph R Bertino, Adriano Aguzzi, Mathias Heikenwalder, Alexander K Knuth   +12 more
doaj   +1 more source

Further phenotypic characterization of the primitive lineage− CD34+CD38−CD90+CD45RA− hematopoietic stem cell/progenitor cell sub-population isolated from cord blood, mobilized peripheral blood and patients with chronic myelogenous leukemia

Blood Cancer Journal, 2011
The most primitive hematopoietic stem cell (HSC)/progenitor cell (PC) population reported to date is characterized as being Lin−CD34+CD38−CD90+CD45R.
D. Wisniewski, M. Affer, J. Willshire, B. Clarkson   +3 more
semanticscholar   +1 more source

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]

, 2019
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A., Fu, Yang-Xin, Han, Chuanhui, Huang, Xiumei, Jiang, Lingxiang, Li, Xiaoguang, Liu, Zhida, Qiao, Jian, Shen, Aijun, Wang, Yang, Zhang, Anli   +10 more
core   +1 more source