Results 131 to 140 of about 475,709 (254)

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Bio-Exploitation of Filamentous Fungi

, 2001
The focus of this exciting new book is on identifying existing and potential applications for filamentous fungi. Selected topics at the forefront of current fungal biotechnology research, namely bioactive compounds and agricultural applications, are ...

core  

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

Cell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu, Bingyu Cai, Tingting Gao, Wumei Wei, Liu Wang, Qi Zhou, Wei Li, Jie Hao, Jun Wu   +8 more
wiley   +1 more source

What are the 100 most cited fungal genera?

The global diversity of fungi has been estimated between 2 to 11 million species, of which only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they represent a major component of biodiversity on our planet, and play ...
Fischer, M., Wang, D.Q., Dijksterhuis, J., Campbell, L.J., Arantes, T.D., Groenewald, J.Z., Phookamsak, R., Dai, Y.C., Salgado-Salazar, C., Scott, P., Morozova, O.V., Stchigel, A.M., Theodoro, R.C., Magurno, F., Maharachchikumbura, S.S.N., Iturrieta-González, I., Custódi, F.A., van den Brule, T., Alvarez Duarte, E., Dissanayake, A.J., Wang, X.W., Phillips, A.J.L., Bai, F.Y., Sterflinger, K., Chethana, K.W.T., Turchetti, B., He, M.Q., Zhao, R.L., Poyntner, C., Wartchow, F., Lachance, M.A., Gené, J., Kandemir, H., Roy, N., de Souza, F.A., Kiss, L., McKenzie, E., Rathnayaka, A.R., Souza-Motta, C.M., Groenewald, M., Loizides, M., Phukhamsakda, C., Promputtha, I., Bradley, C.A., Phonemany, M., Chen, Y.Y., Doilom, M., Wei, D.P., Damm, U., Pordel, A., Torres, R., Chethana, K.W.T., Yilmaz, N., Makhathini Mkhwanazi, G.J., Calaça, F., Osiewacz, H.D., Summerbell, R.C., Luo, K.Y., Moreau, P.A., van den Brule, R., Aiphuk, W., Francisco, E.C., Barbosa, R.N., Bilański, P., Welti, S., Čadež, N., Frisvad, J.C., Luangsa-ard, J., Zhou, N., Gomdola, D., Houbraken, J., Takamatsu, S., Thines, M., Gonkhom, D., Chen, Y.J., Boekhout, T., Spies, C.F.J., Scholler, M., McTaggart, A., McKenzie, E.H.C., Xu, R., Shivas, R.G., Landi, L., Bubner, B., Kobmoo, N., Mostert, L., Guarnaccia, V., Liu, X.B., Liu, J.K., Bezerra, J.D.P., Wijesinghe, S.N., Robert, V., Hyde, K.D., Saupe, S.J., Dutta, A.K., Visagie, C. M., Hagen, F., Błaszkowski, J., Calaça, F.J.S., Álvarez-Duarte, E., Cai, L., Rothmann, L., de Queiroz, M.B., Gomes, A.A.M., Lin, C. G., Buyck, B., Custódio, F.A., Burgess, T. I., Hou, L., Chen, Q., Marin-Felix, Y., Perrone, G., Jayawardena, R.S., Bakhshi, M., Yang, Z..., Silar, P., Pem, D., Araujo, J.C., Thongklang, N., Zhao, L., Wanasinghe, D.N., Braun, U., Tibpromma, S., Hausner, G., Ajayi-Oyetunde, O., Santiago, A.L.C.M.A., Jankowiak, R., Moreau, P. A., Yang, Z.L., Yurkov, A., Silva-Filho, A.G.S., Theelen, B., Dong, W., Li, J.J., Bensch, K., Burgess, T.I., Hurdeal, V.G., Goto, B.T., Jami, F., Wu, F., McTaggart, A.R., Sandoval-Denis, M., Visagie, C.M., De Miccolis Angelin, R.M., Luangharn, T., Kowalski, T., Zhao, C.L., Lin, C.G., Crous, P.W., Rodrigues, A.M., Mongkolsamrit, S., Blaszkowski, J., Coetzee, B., Romanazzi, G., Bhunjun, C.S., Gajanayake, A.J., Begerow, D., Chaverri, P., Manawasinghe, I.S., Svetasheva, T.Y., Costa, M.M., Wang, D.Q,., Behrens, F.H., Pollastro, S.   +163 more
core   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source