Results 181 to 190 of about 35,568 (259)

The roles of salivary secretory IgA on the development of oral candidiasis. [PDF]

open access: yesFront Oral Health
Zhou J   +8 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

open access: yesCell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao   +7 more
wiley   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas   +11 more
wiley   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 8, Page 1318-1331, August 2026.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta   +4 more
wiley   +1 more source

The immunity paradox: how do plants survive without adaptive immunity?

open access: yesThe Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY Higher plants and mammals exist in similar microbial environments and face similar challenges from microbial pathogens. Both taxonomic groups encode proteins capable of recognizing and triggering responses to pathogens; however, their recognitional capacities differ substantially.
Peter Balint‐Kurti
wiley   +1 more source

Vaccine-Mediated Protection of Mice Against African and Asian Clinical Strains of <i>Cryptococcus neoformans</i>. [PDF]

open access: yesJ Fungi (Basel)
Carlson D   +10 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy