Results 81 to 90 of about 35,568 (259)

Will the Real Immunogens Please Stand Up: Exploiting the Immunogenic Potential of Cryptococcal Cell Antigens in Fungal Vaccine Development

Journal of Fungi
Cryptococcus neoformans is an opportunistic fungal pathogen that is a continuous global health concern, especially for immunocompromised populations. The World Health Organization recognized C.
Samantha L. Avina, Siddhi Pawar, Amariliz Rivera, Chaoyang Xue   +3 more
doaj   +1 more source

Contralateral recurrence of allergic fungal rhinosinusitis after unilateral endoscopic sinus surgery: a case report

Acta Oto-Laryngologica Case Reports
Allergic fungal rhinosinusitis (AFRS) is a chronic sinusitis resulting from type I and III hypersensitivity reactions to fungal antigens. We report a rare case of a 30-year-old woman with asthma, allergic dermatitis, and allergic rhinitis who developed ...
Shinji Iwata, Seitaro Murakawa, Naoya Nishida, Naohito Hato   +3 more
doaj   +1 more source

Polycystic Kidney Disease: An Unrecognized Emerging Infectious Disease?

Emerging Infectious Diseases, 1997
Polycystic kidney disease (PKD) is one of the most common genetic diseases in humans. We contend that it may be an emerging infectious disease and/or microbial toxicosis in a vulnerable human subpopulation.
Marcia A. Miller-Hjelle, J. Thomas Hjelle, Monica Jones, William R. Mayberry, Mary Ann Dombrink-Kurtzman, Stephen W. Peterson, Deborah M. Nowak, Frank S. Darras   +7 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

A rare case of Trichosporon inkin bloodstream infection in an immunocompetent patient: Diagnostic challenges and antigenic cross-reactivity

Decoding Infection and Transmission
Trichosporon inkin is a rare opportunistic pathogen typically associated with superficial infections but can also cause invasive infections, particularly in immunocompromised hosts. Here, we report a rare case of T.
Yongqin Wu
doaj   +1 more source

A New Method for Reactivating and Expanding T Cells Specific for Rhizopus oryzae

Molecular Therapy: Methods & Clinical Development, 2018
Mucormycosis is responsible for an increasing proportion of deaths after allogeneic bone marrow transplantation. Because this disease is associated with severe immunodeficiency and has shown resistance to even the newest antifungal agents, we determined ...
Paul Castillo, Kaylor E. Wright, Dimitrios P. Kontoyiannis, Thomas Walsh, Shabnum Patel, Elizabeth Chorvinsky, Swaroop Bose, Yasmin Hazrat, Bilal Omer, Nathaniel Albert, Ann M. Leen, Cliona M. Rooney, Catherine M. Bollard, Conrad Russell Y. Cruz   +13 more
doaj   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Infection risk in rheumatoid arthritis patients treated with biologic and targeted therapies

Rheumatology &Autoimmunity, EarlyView.
In this context, infections associated with each biologic and targeted drug are summarized to inform the stratification of RA patients, including the characteristics of the susceptible patients and their concomitant therapy. We aim to provide a benefit‐risk analysis for clinical decision, and vital indications for the prevention of highly correlated ...
Lujing Wang, Jieshi Lin, Jie Qian
wiley   +1 more source