Results 81 to 90 of about 4,221 (179)

LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT We describe the first immunohistochemical analysis performed on brain lesion biopsies from two young individuals with Fanconi anemia neuroinflammatory syndrome (FANS). We identified aberrant activation of the LINE‐1 retrotransposon as a novel mechanism of neuroinflammation in individuals with hematological disorders.
Allison L. Bartlett, Kristie N. Ramos, Jamen R. Bartlett, Kenneth S. Ramos, Nathan Luebbering, Kasiani C. Myers, Parinda A. Mehta, Stella M. Davies   +7 more
wiley   +1 more source

BK Virus: Opportunity Makes a Pathogen [PDF]

, 2017
More than 70% of the general population worldwide has serological evidence of exposure to Polyomavirus hominis type 1, better known as BK virus (BKV).
Hirsch, Hans H., Snydman, David R.
core  

Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel. [PDF]

, 2017
T-cells play a critical role in tumor immunity. Indeed, the presence of tumor-infiltrating lymphocytes is a predictor of favorable patient prognosis for many indications and is a requirement for responsiveness to immune checkpoint blockade therapy ...
Ackerman, Ahmed, Ansell, Araki, Ascierto, Beatty, Beatty, Blagih, Borkner, Brahmer, Brandacher, Brentjens, Brentjens, Bridgeman, Brocker, Brudno, Buck, Buckanovich, Burnette, Butler, Butler, Carpenito, Caruana, Caruso, Chang, Chang, Chen, Chen, Chen, Cherkassky, Chmielewski, Church, Colegio, Cordoba, Cretenet, Crompton, Cui, Curiel, Curran, Deaglio, Demaria, Doedens, Facciabene, Fesnak, Finney, Fischer, Fousek, Fox, Frauwirth, Frauwirth, Fridman, Fuertes, Gabrilovich, Gajewski, Gajewski, Galon, Gargett, Gattinoni, Gattinoni, Gattinoni, Geiger, Geissmann, Gill, Gobert, Govers, Gracias, Grada, Gross, Gross, Gubin, Gubser, Guest, Guppy, Hall, Hamanishi, Han, Harlin, Herrera, Hinrichs, Hinrichs, Ho, Hodi, Hombach, Hombach, Hombach, Hsu, Huang, Hudecek, Hwang, Iida, Ino, Irving, Italiani, James, Jass, Jensen, Jensen, Ji, Jones, Joyce, June, Justus, Kahlon, Kawalekar, Kerkar, Kershaw, Kershaw, Khalil, Khalil, Klebanoff, Klebanoff, Klebanoff, Klug, Lamers, Lanitis, Lanitis, Larkin, Le, Le, Lee, Li, Lipson, Liu, Liu, Lochner, Long, Louis, Lugli, Lunt, MacIver, Mahoney, Martinez-Forero, Marvel, Maude, Maus, Maus, Mellor, Menetrier-Caux, Mikucki, Miller, Mittal, Moon, Morgan, Morgan, Morsut, Motz, Motz, Motzer, Muniappan, Munn, Munn, Munn, Murdoch, Nghiem, Niederman, Noman, Okamoto, Otsuji, O’Sullivan, O’Sullivan, Palazón, Palmer, Pameijer, Pandiyan, Paolino, Pardoll, Parry, Patsoukis, Pearce, Pegram, Peng, Peng, Pipkin, Pluta, Porter, Powles, Prosser, Rabinovich, Rathmell, Restifo, Rizvi, Rodriguez, Rodriguez, Rosenberg, Rosenberg, Roybal, Salerno, Sallusto, Santoro, Savoldo, Scharping, Schmid, Schwartz, Semenza, Sharpe, Sikalidis, Sinclair, Singh, Sivan, Smith, Snyder, Sommermeyer, Spranger, Spranger, Spranger, Srivastava, Stromnes, Suarez, Sukumar, Sukumar, Tamada, Tan, Taylor, Terakura, Topalian, Topalian, Topalian, Torikai, Tran, Tumeh, Turatti, Urbanska, Uyttenhove, van der Merwe, van der Waart, van der Windt, van der Windt, van der Windt, van Rooij, Vander Heiden, Vuillefroy de Silly, Vuillefroy de Silly, Vétizou, Waickman, Wang, Wang, Wang, Wang, Wang, Warburg, Wherry, Willemsen, Wing, Wofford, Wu, Xu, Yang, Yang, Yaqoob, Zhang, Zhang, Zhang, Zheng   +252 more
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Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, Volume 19, Issue 11, Page 3035-3059, November 2025.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma [PDF]

, 2022
Merkel cell polyomavirus (MCPyV) is a causal factor in Merkel cell carcinoma (MCC). The oncogenic potential is mediated through its viral oncoproteins large T-antigen (LT) and small T-antigen (sT). Cytokines produced by tumor cells play an important role
Johnsen, John Inge, Koljonen, Virve, Lui, Weng-Onn, Moens, Ugo, Policastro, Benedetta, Rasheed, Kashif, Sihto, Harri, Sveinbjørnsson, Baldur   +7 more
core  

Biology of BMP signalling and cancer [PDF]

, 2009
[Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their malignant properties (i.e ...
Aparicio Gallego, Guadalupe, Blanco, Moisés, Bolós Fernández, Victoria, Díaz-Prado, Silvia, Grande Pulido, Enrique, Medina Villaamil, Vanessa   +5 more
core   +2 more sources

Comparative analyses of tumorigenic mechanisms of Merkel cell polyomavirus T antigens [PDF]

, 2020
The work described in this dissertation began in 2013 and is focused on characterizing the mechanisms by which Merkel cell polyomavirus (MCV) Large T (LT) and small T (sT) antigens induce tumorigenesis through comparative analyses with oncoproteins from ...
Wendzicki, Justin
core  

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. [PDF]

, 2015
Matriptase is an epithelia-specific membrane-anchored serine protease that has received considerable attention in recent years because of its consistent dysregulation in human epithelial tumours, including breast cancer.
Bergum, Christopher, Boerner, Julie, Colombo, Éloïc, Lang, Julie E, Leduc, Richard, List, Karin, Marsault, Eric, Molinolo, Alfredo A, Murray, Andrew S, Tanabe, Lauren M, Varela, Fausto A, Zoratti, Gina L   +11 more
core   +1 more source

Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis [PDF]

, 2002
Throughout life, the hematopoietic system requires a supportive microenvironment that allows for the maintenance and differentiation of hematopoietic stem cells (HSC).
Covey, T., Dzierzak, E.A. (Elaine), Harvey, K. (Kirsten), Kusadasi, N. (Nuray), Medvinsky, A.J., Nakayama, N., Oostendorp, R.A. (Robert), Orelio, C., Ottersbach, K. (Katrin), Ploemacher, R.E. (Robert), Saris, C. (Chris)   +10 more
core  

The consequences for human health of stratospheric ozone depletion in association with other environmental factors

, 2014
Due to the implementation of the Montreal Protocol, which has limited, and is now probably reversing, the depletion of the stratospheric ozone layer, only modest increases in solar UV-B radiation at the surface of the Earth have occurred.
de Gruijl, F. R, Lucas, R. M, Neale, R. E, Norval, M, Takizawa, Y, van der Leun, J. C, Young, A. R   +6 more
core   +1 more source