Results 31 to 40 of about 18,678 (181)
Anticancer effects of parasite extracts of leishmaniasis and toxoplasma On resistant cell line (A2780-CP) and sensitive (A2780) to cisplatin [PDF]
زیستشناسی کاربردی, 2018 Cancer is one of the problems of human society that threatens human health. Since anti-cancer drugs have multiple side effects, identification of the biological processes and the protozoan antigens leads to the introduction of suitable candidates.
ameneh Elikaei +2 more
doaj +1 more source
Diagnostics, 2022 Diagnosing and treating many infectious diseases depends on correctly identifying the causative pathogen. Characterization of pathogen-specific nucleic acid sequences by PCR is the most sensitive and specific method available for this purpose, although ...
Jyotsna S. Shah, Ranjan Ramasamy
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A perspective on clonal phenotypic (antigenic) variation in protozoan parasites
Parasitology, 2002 Intra-clonal phenotypic (antigenic) variation is used by many pathogens to evade the consequences of immune-mediated killing by mammalian hosts. In this substantially theoretical article, I emphasise that antigenic variation (sensu stricto) involves no change in genotype; its importance as a mechanism for promoting pathogen transmission and its ...
openaire +2 more sources
Surface antigenic change during differentiation of a parasitic protozoan, Leishmania mexicana: Identification by monoclonal antibodies. [PDF]
Proceedings of the National Academy of Sciences, 1982 The fusion of SP2/0 myeloma cells with spleen cells from mice immunized with Leishmania mexicana amazonensis promastigotes produced hybridoma clones. Indirect immunofluorescent antibody assay with live leishmanias showed that the monoclonal antibody 6H12 recognized only the antigens bound to the surface of L. mexicana amazonensis promastigotes. It also
Fong, D, Chang, K
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Mediators of Inflammation, 2016 Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens.
Liliana M. R. Silva +5 more
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Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva +8 more
wiley +1 more source
Surface antigen cross-linking triggers forced exit of a protozoan parasite from its host. [PDF]
Proceedings of the National Academy of Sciences, 1996 We used the common fish pathogen Ichthyophthirius multifiliis as a model for studying interactions between parasitic ciliates and their vertebrate hosts. Although highly pathogenic, Ichthyophthirius can elicit a strong protective immune response in fish after exposure to controlled infections. To investigate the mechanisms underlying host resistance, a
T G, Clark, T L, Lin, H W, Dickerson
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Frontiers in Immunology, 2014 Visceral leishmaniasis is a neglected infectious disease caused primarily by Leishmania donovani and L. infantum protozoan parasites. A significant number of infections take a fatal course.
Anton eAebischer
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Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania [PDF]
Biochemical Journal, 1989 Fragments of the lipophosphoglycan of Leishmania donovani were generated by phospholipase C digestion and mild acid hydrolysis. The fragments were purified and examined for inhibitory activity on protein kinase C isolated from rat brains. On a molar basis, the 1-O-alkylglycerol portion of LPG exhibited the most inhibitory activity, whereas the ...
T B, McNeely +3 more
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