Results 61 to 70 of about 18,678 (181)

Genome-wide screening and identification of new Trypanosoma cruzi antigens with potential application for chronic Chagas disease diagnosis.

PLoS ONE, 2014
The protozoan Trypanosoma cruzi is the etiologic agent of Chagas disease, an infection that afflicts approximately 8 million people in Latin America. Diagnosis of chronic Chagas disease is currently based on serological tests because this condition is ...
João Luís Reis-Cunha, Tiago Antônio de Oliveira Mendes, Rodrigo de Almeida Lourdes, Daihana Rodrigues dos Santos Ribeiro, Ricardo Andrez Machado-de-Avila, Maykon de Oliveira Tavares, Denise Silveira Lemos, Antônia Cláudia Jácome Câmara, Carlos Chavez Olórtegui, Marta de Lana, Lúcia Maria da Cunha Galvão, Ricardo Toshio Fujiwara, Daniella Castanheira Bartholomeu   +12 more
doaj   +1 more source

IL‐33/ST2 Signaling Sustains Hepato‐Intestinal Homeostasis by Orchestrating Vascular Surveillance and Immune Regulatory Circuits During Experimental Trypanosoma cruzi Infection

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Impairment of hepato‐intestinal homeostasis triggered by ST2 deficiency during T. cruzi infection. Within the splenic compartment, immune dysregulation is marked by a robust pro‐inflammatory polarization of the T‐cell landscape. In the liver, ST2 deficiency is associated with hepatocellular injury, increased parasite burden, and hyperalbuminemia ...
Marcelo Eduardo Cardozo, Tatyane Martins Cirilo, José Bryan da Rocha Rihs, Jorge Lucas Nascimento Souza, Isabela de Brito Duval, Ana Rafaela Antunes‐Porto, Luisa Vitor Braga do Amaral, Fernando Bento Rodrigues Oliveira, Mayra Fernanda Ricci, Laura Lis de Oliveira Santos, Lívia Fernanda Dias Santana, Luiza Pinheiro Silva, Chiara Cássia Oliveira Amorim, Gabriela Gomes Monteiro Lemos, Getulío Mota e Silva Junior, Izabela da Silva Oliveira, Marina Possa dos Reys, Ana Laura Grossi de Oliveira, Geovanni Dantas Cassali, Luisa Mourão Dias Magalhães, Lilian Lacerda Bueno, Fabiana Simão Machado, Ricardo Toshio Fujiwara   +22 more
wiley   +1 more source

Expression, characterisation and antigenicity of a truncated Hendra virus attachment protein expressed in the protozoan host Leishmania tarentolae

Journal of Virological Methods, 2016
Hendra virus (HeV) is an emerging zoonotic paramyxovirus within the genus Henipavirus that has caused severe morbidity and mortality in humans and horses in Australia since 1994. HeV infection of host cells is mediated by the membrane bound attachment (G) and fusion (F) glycoproteins, that are essential for receptor binding and fusion of viral and ...
Fischer, Kerstin, dos Reis, Vinicius Pinho, Finke, Stefan, Sauerhering, Lucie, Stroh, Eileen, Karger, Axel, Maisner, Andrea, Groschup, Martin H., Diederich, Sandra, Balkema-Buschmann, Anne   +9 more
openaire   +2 more sources

Antibody response induced by structural proteins from Triatoma virus as potential adjuvants in experimental immunisation models

Frontiers in Microbiology
IntroductionVirus-Like Particles (VLPs) are viral protein structures widely used as adjuvants in vaccine formulations due to their ability to stimulate the innate immune response, thereby contributing to the activation of adaptive immunity through the ...
Aline Maria Vasconcelos Queiroz, Aline Maria Vasconcelos Queiroz, Annamairlla do Nascimento Oliveira, Annamairlla do Nascimento Oliveira, Alzira Regina Silva de Deus, Alzira Regina Silva de Deus, Ingrid Emiliane Fonseca de Oliveira, Isaías Amâncio dos Santos, Fred Luciano Neves Santos, Paola Alejandra Fiorani Celedon, Diego M. A. Guérin, Ana Rosa Viguera, Marcelo Sousa-Silva, Marcelo Sousa-Silva, Marcelo Sousa-Silva   +14 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, Volume 13, Issue 39, 13 July 2026.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Leishmania tarentolae as a platform for the production of vaccines against viral pathogens

npj Vaccines
Infectious diseases remain a persistent public health problem and a leading cause of morbidity and mortality in both humans and animals. The most effective method of combating viral infections is the widespread use of prophylactic vaccinations, which are
Marta Zimna, Ewelina Krol
doaj   +1 more source

Discovery of new Toxoplasma gondii antigenic proteins using a high throughput protein microarray approach screening sera of murine model infected orally with oocysts and tissue cysts

Parasites & Vectors, 2018
Background Toxoplasma gondii is an obligate intracellular protozoan parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations in immune compromised humans.
Mert Döşkaya, Li Liang, Aarti Jain, Hüseyin Can, Sultan Gülçe İz, Philip Louis Felgner, Aysu Değirmenci Döşkaya, David Huw Davies, Adnan Yüksel Gürüz   +8 more
doaj   +1 more source

Interplay Between Infectious Diseases and the Endocrine System: An Overview and Clinical Insights

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Infectious diseases can disrupt endocrine homeostasis through direct cytopathic injury, autoimmune dysregulation, or pathogen‐derived hormone‐like effects. Viruses and bacteria are the most frequent agents, whereas fungi and parasites contribute less commonly, even remaining clinically relevant, especially in the immunocompromised population.
Francesco Capoccia, Valentina D'Onghia, Valentina Semeraro, Esposito Susanna, Maria Elisabeth Street   +4 more
wiley   +1 more source

Comparative Transcriptomics of the Bovine Apicomplexan Parasite Theileria parva Developmental Stages Reveals Massive Gene Expression Variation and Potential Vaccine Antigens

Frontiers in Veterinary Science, 2020
Theileria parva is a protozoan parasite that causes East Coast fever (ECF), an economically important disease of cattle in Africa. It is transmitted mainly by the tick Rhipicephalus appendiculatus.
Kodzo Atchou, Kodzo Atchou, Juliette Ongus, Eunice Machuka, Eunice Machuka, John Juma, Christian Tiambo, Appolinaire Djikeng, Joana C. Silva, Joana C. Silva, Roger Pelle   +10 more
doaj   +1 more source

Clinical and Diagnostic Considerations in Laryngeal Leishmaniasis: A Systematic Review

OTO Open, Volume 10, Issue 3, July-September 2026.
Abstract Objective Laryngeal leishmaniasis is a rare, insidious manifestation of Leishmania infection with potential for life‐threatening complications. Awareness is critical for efficient and timely diagnosis. This systematic review of laryngeal leishmaniasis focuses on presentation, treatment, and the role of serological studies in the work up of ...
Joseph Celidonio, Nicholas Hamilton, Alexandra Filipkowski, Raj Malhotra, Samantha Shave, Myat E. Mon, Kenneth Yan, Rachel Kaye   +7 more
wiley   +1 more source