Results 91 to 100 of about 557,005 (309)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Monoclonal Antibody Production against Human Spermatozoal Surface Antigens

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2005
Introduction: As monoclonal antibodies are potential tools for characterization of soluble or cellular surface antigens, use of these proteins has always been considered in infertility and reproduction research.
M Jedi-Tehrani, F Shokri, A Dizeji, MR Sadeghi, R Ghods, M Heidari, AA Bayat, E Tork-Abadi, MM Akhoundi   +8 more
doaj  

Anchoring of proteins to lactic acid bacteria [PDF]

, 1999
The anchoring of proteins to the cell surface of lactic acid bacteria (LAB) using genetic techniques is an exciting and emerging research area that holds great promise for a wide variety of biotechnological applications. This paper reviews five different
A Hoick, A Mercenier, A Robert, A Strauss, A Strauss, AJ Haandrikman, AP Pugsley, C Andréoni, CBM Maassen, CM Franke, CM Franke, CM Rush, D Medaglini, D Medaglini, D Medaglini, E Gunneriusson, FO Eko, G Buist, G Buist, G Georgiou, G Pozzi, G Pozzi, G Pozzi, G Pozzi, G Pozzi, G Vidgrén, H Ton-That, H Ton-That, HJ Boot, I Poquet, J Kok, JC Piard, JM Wells, K Robinson, L Steidler, M, M Hansson, M Hofnung, ML Callegari, MR Oggioni, MR Oggioni, O Schneewind, O Schneewind, O Schneewind, P Samuelson, P Vos, PH Pouwels, PH Pouwels, PM Norton, PM Norton, RJ Leer, S Fabio, S Liljeqvist, S Ricci, S Stahl, S Tynkkynen, SC Cebolla, T Toba, TN Nguyen, TN Nguyen, UB Sleytr, VA Fischetti, VA Fischetti, VA Fischetti, WW Navarre, WW Navarre, WW Navarre   +66 more
core   +1 more source

Surface Antigenic Variation in Giardia Lamblia [PDF]

Molecular Microbiology, 2002
Summary Giardia lamblia , a common intestinal dwelling protozoan and a cause of diarrhoea in humans and animals world‐wide, undergoes surface antigenic variation. The variant‐specific surface proteins (VSPs) are a family of related, highly unusual proteins that cover the entire surface of the parasite.
openaire   +4 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]

, 2009
Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora, A Scheffold, AF Setiadi, AM Pearse, Ariberto Fassati, B Comin-Anduix, B Kavanagh, B Muller-Hilke, C Murgia, CA Rebbeck, CC Chang, CL Yauk, CM Gonzalez, CM Koebel, CY Lin, D Cohen, D Cohen, D Cohen, D Cohen, E Ambrosino, E Klein, E Mozos, ED Carosella, ED Carosella, EK Geissler, FR Depontieu, G Willimsky, GD Snell, GP Dunn, GP Dunn, GP Dunn, H Ikeda, H McCallum, H Wajant, HV Siddle, HV Siddle, I Kryczek, J Galon, J Hori, J Perez, J Zhou, K Kretschmer, K Masuda, K Milne, KJ Malmberg, KL Wright, L Tian, L Vago, L Yip, M Bleakley, M Campoli, M Gerloni, M Mammolenti, M Mehling, M Novinski, M Pierobon, M Shackleton, M Thornley, MA Cheever, MN Scherer, N Mitchison, N Schwinn, N. Avrion Mitchison, NA Mitchison, NM Moutsopoulos, P Jimenez, PC Chou, R Mendez, R Mendez, R Uppaluri, S Lob, S Verheyden, SM Kang, SR Choudhury, T Akagi, T Cabrera, T Isoda, T Marchal, T Rodriguez, TJ Yang, TJ Yang, W Reith, YC Chang, YW Hsiao, YW Hsiao   +84 more
core   +2 more sources

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species

Frontiers in Immunology, 2019
The surface transferrin receptor proteins from Neisseria gonorrhoeae have been recognized as ideal vaccine targets due to their critical role in survival in the human male genitourinary tract. Recombinant forms of the surface lipoprotein component of the
Jamie E. Fegan, Jamie E. Fegan, Charles Calmettes, Epshita A. Islam, Sang Kyun Ahn, Somshukla Chaudhuri, Rong-hua Yu, Scott D. Gray-Owen, Trevor F. Moraes, Anthony B. Schryvers   +9 more
doaj   +1 more source