Results 31 to 40 of about 376,600 (264)

Bacterial Spore-Based Delivery System: 20 Years of a Versatile Approach for Innovative Vaccines

Biomolecules, 2023
Mucosal vaccines offer several advantages over injectable conventional vaccines, such as the induction of adaptive immunity, with secretory IgA production at the entry site of most pathogens, and needle-less vaccinations.
Rachele Isticato
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study

Frontiers in Immunology
ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Weiming Sun, Weiming Sun, Weiming Sun, Jiawei Gui, Keqi Wan, Keqi Wan, Yize Cai, Xiangli Dong, Guohua Yu, Guohua Yu, Chafeng Zheng, Chafeng Zheng, Zhen Feng, Zhen Feng, Zhen Feng, Lang Shuai, Lang Shuai   +16 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Identification and Characterization of the Antigens Expressed on the Surface of Human Erythrocytes Infected With Plasmodium Falciparum

Iranian Journal of Parasitology, 2013
Background: Molecules expressed on the surface of infected erythrocytes (IE) with Plasmodium falcipa­rum play important roles in malaria pathogenesis and immune evasion.
S Ghaffari, N Kalantari
doaj   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cloning, expression and purification of a polytopic antigen comprising of surface antigens of Toxoplasma gondii

Iranian Journal of Microbiology, 2017
Background and Objectives: Polytopic antigens are recently applied for replacing crude antigens, for control of infectious agents. The surface of the Toxoplasma is covered with immunogenic antigens namely surface antigens (SAGs).
Abbas Alibakhshi, Mojgan Bandehpour, Bahram Kazemi   +2 more
doaj  

Rapid and specific biotin labelling of the erythrocyte surface antigens of both cultured and ex-vivo Plasmodium parasites

Malaria Journal, 2007
Background Sensitive detection of parasite surface antigens expressed on erythrocyte membranes is necessary to further analyse the molecular pathology of malaria.
Thompson Joanne, Sowa Kordai MP, Sharling Lisa, Kyriacou Helen M, Arnot David E   +4 more
doaj   +1 more source

Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. [PDF]

PLoS ONE, 2011
Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens.
Tim J Schuijt, Sukanya Narasimhan, Sirlei Daffre, Kathleen DePonte, Joppe W R Hovius, Cornelis Van't Veer, Tom van der Poll, Kamran Bakhtiari, Joost C M Meijers, Eric T Boder, Alje P van Dam, Erol Fikrig   +11 more
doaj   +1 more source