Results 31 to 40 of about 384,075 (266)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages

Retrovirology, 2007
Background Expression levels of cell surface antigens such as CD38 and HLA-DR are related to HIV disease stages. To date, the immunophenotyping of cell surface antigens relies on flow cytometry, allowing estimation of 3–6 markers at a time.
Cunningham Anthony L, Zaunders John, Dyer Wayne B, Learmont Jenny, Chrisp Jeremy, Belov Larissa, Wang Bin, Wu Jing, Dwyer Dominic E, Saksena Nitin K   +9 more
doaj   +1 more source

A Novel Methodology for Detecting Variations in Cell Surface Antigens Using Cell-Tearing by Optical Tweezers

Biosensors, 2022
The quantitative analysis of cell surface antigens has attracted increasing attention due to the antigenic variation recognition that can facilitate early diagnoses.
Chih-Lang Lin, Shyang-Guang Wang, Meng-Tsung Tien, Chung-Han Chiang, Yi-Chieh Lee, Patrice L. Baldeck, Chow-Shing Shin   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Preparing Adjuvanted Nanoliposomes for Applications Toward Recombinant Influenza Vaccine Development

Bio-Protocol
Nanoparticle vaccines can provide advantages over traditional vaccine methodologies, including adjuvant delivery to enhance the effectiveness of recombinant antigens.
Zachary Sia, Wei-Chiao Huang, Matthew Willadsen, Hilliard Kutscher, Jonathan Lovell, Bruce Davidson   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Pooled protein immunization for identification of cell surface antigens in Streptococcus sanguinis. [PDF]

PLoS ONE, 2010
Available bacterial genomes provide opportunities for screening vaccines by reverse vaccinology. Efficient identification of surface antigens is required to reduce time and animal cost in this technology.
Xiuchun Ge, Todd Kitten, Cindy L Munro, Daniel H Conrad, Ping Xu   +4 more
doaj   +1 more source

Bacterial Spore-Based Delivery System: 20 Years of a Versatile Approach for Innovative Vaccines

Biomolecules, 2023
Mucosal vaccines offer several advantages over injectable conventional vaccines, such as the induction of adaptive immunity, with secretory IgA production at the entry site of most pathogens, and needle-less vaccinations.
Rachele Isticato
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Causal effects of immune cell surface antigens and functional outcome after ischemic stroke: a Mendelian randomization study

Frontiers in Immunology
ObjectiveWhile observational studies link immune cells with post-stroke functional outcome, the underlying immune mechanisms are not well understood.
Weiming Sun, Weiming Sun, Weiming Sun, Jiawei Gui, Keqi Wan, Keqi Wan, Yize Cai, Xiangli Dong, Guohua Yu, Guohua Yu, Chafeng Zheng, Chafeng Zheng, Zhen Feng, Zhen Feng, Zhen Feng, Lang Shuai, Lang Shuai   +16 more
doaj   +1 more source